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Title: Comparing two antibacterial treatments for bioceramic coatings at short culture times
Author: Melero, H.
Madrid Xufré, Cristina
Fernández González, Javier
Guilemany, J. M. (José María)
Keywords: Hidroxiàcids
Plasma sanguini
Medicaments antibacterians
Materials biomèdics
Hydroxy acids
Blood plasma
Antibacterial agents
Biomedical materials
Issue Date: 28-Jan-2014
Publisher: ASM International
Abstract: Plasma-sprayed hydroxyapatite coatings were employed industrially for decades to improve osteointegration of articular implants, but many studies have warned about the problems inherent to this procedure (mechanical properties, harmful phases). Consequently, a combination of hydroxyapatite with TiO2 sprayed by high velocity oxy-fuel spray was considered in this study. As infection after joint replacement surgery is one of the most critical concerns when considering implant performance, it is necessary to study possible ways to reduce or eliminate it. Two coating treatments were chosen for this study: addition of a percentage of ZnO and immersion in gentamicin for 24 h. Furthermore, three bacteria were considered: Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The evolution of bacteria viability in solution was measured at 0, 2, and 4 h; and plate assays were performed to study antibacterial effects by diffusion. The results show an important antibacterial effect of the as-sprayed coating, attributed to the presence of -OH radicals on the surface. The presence of ZnO did not have any additional influence on bacteria viability, but gentamicin-treated samples showed an improvement in antibacterial behavior for Gram-negative bacteria in solution, as well as a bactericidal effect in diffusion conditions.
Note: Reproducció del document publicat a:
It is part of: Journal of Thermal Spray Technology, 2014, vol. 23, num. 4, p. 684-691
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ISSN: 1059-9630
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Ciència dels Materials i Química Física)

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