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Title: A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides
Author: Martín Gómez, Helena
Oliver-Cervelló, Lluís
Sánchez Campillo, Iván
Marchán Sancho, Vicente
Ginebra, Maria Pau
Mas Moruno, Carlos
Keywords: Materials biomèdics
Biomedical materials
Issue Date: 4-Jan-2021
Publisher: Royal Society of Chemistry
Abstract: A novel and versatile toolkit approach for the functionalization of biomaterials of different nature is described. This methodology is based on the solid-phase conjugation of specific anchoring units onto a resin-bound azido-functionalized peptide by using click chemistry. A synergistic multifunctional peptidic scaffold with cell adhesive properties was used as a model compound to showcase the versatility of this new approach. Titanium, gold and polylactic acid surfaces were biofunctionalized by this method, as validated by physicochemical surface characterization with XPS. In vitro assays using mesenchymal stem cells showed enhanced cell adhesion on the functionalized samples, proving the capacity of this strategy to efficiently bioactivate different types of biomaterials.
Note: Versió postprint del document publicat a:
It is part of: Chemical Communications, 2021, vol. 57, num. 8, p. 982-985
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ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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