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Title: Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders
Author: Carvalho, André F.
Solmi, Marco
Sanches, Marcos
Machado, Myrela o.
Stubbs, Brendon
Ajnakina, Olesya
Sherman, Chelsea
Sun, Yue Ran
Liu, Celina S.
Brunoni, Andre R.
Pigato, Giorgio
Fernandes, Brisa S.
Bortolato, Beatrice
Husain, Muhammad I.
Dragioti, Elena
Firth, Joseph
Cosco, Theodore D.
Maes, Michael
Berk, Michael
Lanctôt, Krista L.
Vieta i Pascual, Eduard, 1963-
Pizzagalli, Diego A.
Smith, Lee
Fusar-Poli, Paolo
Kurdyak, Paul A.
Fornaro, Michele
Rehm, Jürgen
Herrmann, Nathan
Keywords: Malalties mentals
Marcadors bioquímics
Mental illness
Biochemical markers
Issue Date: 18-May-2020
Publisher: Nature Publishing Group
Abstract: The literature on non-genetic peripheral biomarkers for major mental disorders is broad, with conflicting results. An umbrella review of meta-analyses of non-genetic peripheral biomarkers for Alzheimer's disease, autism spectrum disorder, bipolar disorder (BD), major depressive disorder, and schizophrenia, including first-episode psychosis. We included meta-analyses that compared alterations in peripheral biomarkers between participants with mental disorders to controls (i.e., between-group meta-analyses) and that assessed biomarkers after treatment (i.e., within-group meta-analyses). Evidence for association was hierarchically graded using a priori defined criteria against several biases. The Assessment of Multiple Systematic Reviews (AMSTAR) instrument was used to investigate study quality. 1161 references were screened. 110 met inclusion criteria, relating to 359 meta-analytic estimates and 733,316 measurements, on 162 different biomarkers. Only two estimates met a priori defined criteria for convincing evidence (elevated awakening cortisol levels in euthymic BD participants relative to controls and decreased pyridoxal levels in participants with schizophrenia relative to controls). Of 42 estimates which met criteria for highly suggestive evidence only five biomarker aberrations occurred in more than one disorder. Only 15 meta-analyses had a power >0.8 to detect a small effect size, and most (81.9%) meta-analyses had high heterogeneity. Although some associations met criteria for either convincing or highly suggestive evidence, overall the vast literature of peripheral biomarkers for major mental disorders is affected by bias and is underpowered. No convincing evidence supported the existence of a trans-diagnostic biomarker. Adequately powered and methodologically sound future large collaborative studies are warranted.
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It is part of: Translational Psychiatry, 2020, vol. 10, num. 152
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ISSN: 2158-3188
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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