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http://hdl.handle.net/2445/174213
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DC Field | Value | Language |
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dc.contributor.author | Cordero, Elisa | - |
dc.contributor.author | Bulnes Ramos, Angel | - |
dc.contributor.author | Aguilar Guisado, Manuela | - |
dc.contributor.author | González Escribano, Francisca | - |
dc.contributor.author | Olivas, Israel | - |
dc.contributor.author | Torre Cisneros, Julián | - |
dc.contributor.author | Gavaldà, Joan | - |
dc.contributor.author | Aydillo, Teresa | - |
dc.contributor.author | Moreno, Asunción | - |
dc.contributor.author | Montejo, Miguel | - |
dc.contributor.author | Fariñas, María Carmen | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.contributor.author | Muñoz, Patricia | - |
dc.contributor.author | Blanes, Marino | - |
dc.contributor.author | Fortún, Jesús | - |
dc.contributor.author | Suarez Benjumea, Alejandro | - |
dc.contributor.author | López Medrano, Francisco | - |
dc.contributor.author | Roca, Cristina | - |
dc.contributor.author | Lara, Rosario | - |
dc.contributor.author | Pérez Romero, Pilar | - |
dc.date.accessioned | 2021-02-23T18:57:24Z | - |
dc.date.available | 2021-02-23T18:57:24Z | - |
dc.date.issued | 2020-10-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174213 | - |
dc.description.abstract | Introduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA(TM)Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch. Results: We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%;P= 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developedde novoanti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA. Conclusion: Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2020.01917 | - |
dc.relation.ispartof | Frontiers in Immunology, 2020, vol. 11 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2020.01917 | - |
dc.rights | cc by (c) Cordero et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Citomegalovirus | - |
dc.subject.classification | Influenzavirus | - |
dc.subject.classification | Vacunes antivíriques | - |
dc.subject.other | Cytomegaloviruses | - |
dc.subject.other | Influenza viruses | - |
dc.subject.other | Viral vaccines | - |
dc.title | Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-02-08T10:28:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33123119 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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File | Description | Size | Format | |
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CorderoE.pdf | 724.59 kB | Adobe PDF | View/Open |
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