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http://hdl.handle.net/2445/174260| Title: | ERBB2mRNA expression and response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-positive breast cancer |
| Author: | Griguolo, Gaia Brasó Maristany, Fara Gonzalez Farré, Blanca Pascual, Tomás Chic, Núria Saurí, Tamara Kates, Ronald Gluz, Oleg Martínez, Débora Paré, Laia Tsvetkova, Vassilena Pesantez, David Vidal Losada, Maria Jesús Adamo, Barbara Muñoz Mateu, Montserrat Galván, Patricia Barberá, Laura Cuatrecasas Freixas, Miriam Christgen, Mathias Kreipe, Hans Monge Escartín, Inés Villagrasa, Patricia Soy Muner, Dolors Giarratano, Tommaso Dieci, Maria Vittoria Conte, Pierfranco Harbeck, Nadia Guarneri, Valentina Prat Aparicio, Aleix |
| Keywords: | Càncer de mama Receptors d'hormones Breast cancer Hormone receptors |
| Issue Date: | 14-Jul-2020 |
| Publisher: | MDPI |
| Abstract: | Trastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and for residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that the heterogeneity in the response seen in patients is partly explained by the levels of human epidermal growth factor receptor 2 gene (ERBB2) mRNA.We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed para n-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1. The association of ERBB2 levels and response was further validated in 161 baseline tumors from the West German Study (WGS) Group ADAPT phase II trial exploring neoadjuvant T-DM1 and 9 in vitro BC cell lines. Finally, |
| Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers12071902 |
| It is part of: | Cancers, 2020, vol. 12(7), num. 1902 |
| URI: | http://hdl.handle.net/2445/174260 |
| Related resource: | https://doi.org/10.3390/cancers12071902 |
| ISSN: | 2072-6694 |
| Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Medicina) |
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