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http://hdl.handle.net/2445/174286
Title: | Nano-engineering of ketorolac tromethamine platforms for ocular treatment of inflammatory disorders |
Author: | Mallandrich Miret, Mireia Calpena Campmany, Ana Cristina Clares Naveros, Beatriz Parra Coca, Alexander García López, María Luisa Soriano-Ruiz, José L. Francisco Fernández-Campos |
Keywords: | Oftàlmia Agents antiinflamatoris Nanopartícules Administració de medicaments Ophthalmia Antiinflammatory agents Nanoparticles Administration of drugs |
Issue Date: | 15-Feb-2021 |
Publisher: | Future Medicine |
Abstract: | Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment of inflammatory processes of the eye. Materials & methods: KT-NPs were developed by factorial design and characterized by assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy and bioavailability tests were performed on pigs. Results: Optimized KT-NPs of 112 nm, narrow distribution with encapsulation efficiency near 100% were obtained. KT release followed the Weibull model and there was significantly greater retention in the cornea and sclera than in the commercial reference. KT-NPs showed no signs of ocular irritancy and similar anti-inflammatory efficacy to the commercial reference. Conclusion: KT-NPs were a suitable alternative for the treatment of inflammatory disorders of the anterior and posterior segments of the eye as an alternative to conventional topical formulations. |
Note: | Versió postprint del document publicat a: https://doi.org/10.2217/nnm-2020-0403 |
It is part of: | Nanomedicine, 2021, vol. 13, num. 3 |
URI: | http://hdl.handle.net/2445/174286 |
Related resource: | https://doi.org/10.2217/nnm-2020-0403 |
ISSN: | 1743-5889 |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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