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http://hdl.handle.net/2445/174293
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DC Field | Value | Language |
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dc.contributor.author | Koelsche, Christian | - |
dc.contributor.author | Schrimpf, Daniel | - |
dc.contributor.author | Stichel, Damian | - |
dc.contributor.author | Sill, Martin | - |
dc.contributor.author | Sahm, Felix | - |
dc.contributor.author | Reuss, David E. | - |
dc.contributor.author | Blattner, Mirjam | - |
dc.contributor.author | Worst, Barbara | - |
dc.contributor.author | Heilig, Christoph E. | - |
dc.contributor.author | Beck, Katja | - |
dc.contributor.author | Horak, Peter | - |
dc.contributor.author | Mautner, Victor-Felix | - |
dc.contributor.author | Schittenhelm, Jens | - |
dc.contributor.author | Serrano, Jonathan | - |
dc.contributor.author | Snuderl, Matija | - |
dc.contributor.author | Büttner, Reinhard | - |
dc.contributor.author | Klingebiel, Thomas | - |
dc.contributor.author | Buslei, Rolf | - |
dc.contributor.author | Gessler, Manfred | - |
dc.contributor.author | Wesseling, Pieter | - |
dc.contributor.author | Brandner, Sebastian | - |
dc.contributor.author | Jaunmuktane, Zane | - |
dc.contributor.author | Dinjens, Winand N. M. | - |
dc.contributor.author | Lyskjær, Iben | - |
dc.contributor.author | Schirmacher, Peter | - |
dc.contributor.author | Stenzinger, Albrecht | - |
dc.contributor.author | Brors, Benedikt | - |
dc.contributor.author | Glimm, Hanno | - |
dc.contributor.author | Heining, Christoph | - |
dc.contributor.author | Tirado, Oscar M. | - |
dc.contributor.author | Sáinz Jaspeado, Miguel Guillermo | - |
dc.contributor.author | Alonso, Javier | - |
dc.contributor.author | García del Muro Solans, Xavier | - |
dc.contributor.author | Mora Salvador, Jaume | - |
dc.contributor.author | Moran, Sebastian | - |
dc.contributor.author | Esteller, Manel | - |
dc.contributor.author | Benhamida, Jamal K. | - |
dc.contributor.author | Ladanyi, Marc | - |
dc.contributor.author | Wardelmann, Eva | - |
dc.contributor.author | Antonescu, Cristina | - |
dc.contributor.author | Flanagan, Adrienne | - |
dc.contributor.author | Dirksen, Uta | - |
dc.contributor.author | Baumhoer, Daniel | - |
dc.contributor.author | Hartmann, Wolfgang | - |
dc.contributor.author | Hohenberger, Peter | - |
dc.contributor.author | Vokuhl, Christian | - |
dc.contributor.author | Flucke, Uta | - |
dc.contributor.author | Petersen, Iver | - |
dc.contributor.author | Mechtersheimer, Gunhild | - |
dc.contributor.author | Capper, David | - |
dc.contributor.author | Jones, David T. W. | - |
dc.contributor.author | Fröhling, Stefan | - |
dc.contributor.author | Pfister, Stefan M. | - |
dc.contributor.author | Kreutzfeldt, Simon | - |
dc.contributor.author | Paff, Elke | - |
dc.contributor.author | von Deimling, Andreas | - |
dc.contributor.author | Stark, Sebastian | - |
dc.contributor.author | Johann, Pascal | - |
dc.contributor.author | Selt, Florian | - |
dc.contributor.author | Ecker, Jonas | - |
dc.contributor.author | Sturm, Dominik | - |
dc.contributor.author | Pajtler, Kristian W. | - |
dc.contributor.author | Reinhardt, Annekathrin | - |
dc.contributor.author | Wefers, Annika K. | - |
dc.contributor.author | Sievers, Philipp | - |
dc.contributor.author | Suwala, Abigail | - |
dc.contributor.author | Ebrahimi, Azadeh | - |
dc.contributor.author | Fernández Klett, Francisco | - |
dc.contributor.author | Casalini, Belén | - |
dc.contributor.author | Korshunov, Andrey | - |
dc.contributor.author | Hovestadt, Volker | - |
dc.contributor.author | Kommoss, Felix K. F. | - |
dc.contributor.author | Kriegsmann, Mark | - |
dc.contributor.author | Schick, Matthias | - |
dc.contributor.author | Bewerunge-Hudler, Melanie | - |
dc.contributor.author | Milde, Till | - |
dc.contributor.author | Kulozik, Andreas E. | - |
dc.contributor.author | Witt, Olaf | - |
dc.contributor.author | Kool, Marcel | - |
dc.contributor.author | Romero-pérez, Laura | - |
dc.contributor.author | Grünewald, Thomas G. P. | - |
dc.contributor.author | Kirchner, Thomas | - |
dc.contributor.author | Wick, Wolfgang | - |
dc.contributor.author | Platten, Michael | - |
dc.contributor.author | Unterberg, Andreas | - |
dc.contributor.author | Uhl, Matthias | - |
dc.contributor.author | Abdollahi, Amir | - |
dc.contributor.author | Lehner, Burkhard | - |
dc.contributor.author | Debus, Jürgen | - |
dc.contributor.author | Thomas, Christian | - |
dc.contributor.author | Hasselblatt, Martin | - |
dc.contributor.author | Paulus, Werner | - |
dc.contributor.author | Hartmann, Christian | - |
dc.contributor.author | Staszewski, Ori | - |
dc.contributor.author | Prinz, Marco | - |
dc.contributor.author | Hench, Jürgen | - |
dc.contributor.author | Frank, Stephan | - |
dc.contributor.author | Versleijen-Jonkers, Yvonne M. H. | - |
dc.contributor.author | Mentzel, Thomas | - |
dc.contributor.author | Weidema, Marije E. | - |
dc.contributor.author | Griewank, Klaus | - |
dc.contributor.author | Álava, Enrique de | - |
dc.contributor.author | Martín, Juan Díaz | - |
dc.contributor.author | Idoate Gastearena, Miguel A. | - |
dc.contributor.author | Chang, Kenneth Tou-En | - |
dc.contributor.author | Low, Sharon Yin Yee | - |
dc.contributor.author | Cuevas-Bourdier, Adrian | - |
dc.contributor.author | Mittelbronn, Michel | - |
dc.contributor.author | Mynarek, Martin | - |
dc.contributor.author | Schüller, Ulrich | - |
dc.contributor.author | Rutkowski, Stefan | - |
dc.date.accessioned | 2021-02-25T10:00:03Z | - |
dc.date.available | 2021-02-25T10:00:03Z | - |
dc.date.issued | 2021-01-21 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174293 | - |
dc.description.abstract | Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-020-20603-4 | - |
dc.relation.ispartof | Nature Communications, 2021, vol. 12 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-020-20603-4 | - |
dc.rights | cc by (c) Koelsche et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Sarcoma | - |
dc.subject.classification | ADN | - |
dc.subject.other | Sarcoma | - |
dc.subject.other | DNA | - |
dc.title | Sarcoma classification by DNA methylation profiling | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 716103 | - |
dc.date.updated | 2021-02-25T09:38:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33479225 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
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s41467-020-20603-4.pdf | 2.44 MB | Adobe PDF | View/Open |
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