Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/174370
Title: Mycolicibacterium brumae is a safe and non-toxic immunomodulatory agent for cancer treatment
Author: Bach Griera, Marc
Campo Pérez, Víctor
Barbosa, Sandra
Traserra, Sara
Guallar Garrido, Sandra
Moya Andérico, Laura
Herrero Abadía, Paula
Luquin, Marina
Rabanal, Rosa María
Torrents Serra, Eduard
Julián, Esther
Keywords: Àcids grassos
Càncer
Fatty acids
Cancer
Issue Date: 25-Apr-2020
Publisher: MDPI
Abstract: Intravesical Mycobacterium bovis Bacillus Calmette-Guérin (BCG) immunotherapy remains the gold-standard treatment for non-muscle-invasive bladder cancer patients, even though half of the patients develop adverse events to this therapy. On exploring BCG-alternative therapies, Mycolicibacterium brumae, a nontuberculous mycobacterium, has shown outstanding anti-tumor and immunomodulatory capabilities. As no infections due to M. brumae in humans, animals, or plants have been described, the safety and/or toxicity of this mycobacterium have not been previously addressed. In the present study, an analysis was made of M. brumae- and BCG-intravenously-infected severe combined immunodeficient (SCID) mice, M. brumae-intravesically-treated BALB/c mice, and intrahemacoelic-infected-Galleria mellonella larvae. Organs from infected mice and the hemolymph from larvae were processed to count bacterial burden. Blood samples from mice were also taken, and a wide range of hematological and biochemical parameters were analyzed. Finally, histopathological alterations in mouse tissues were evaluated. Our results demonstrate the safety and non-toxic profile of M. brumae. Di erences were observed in the biochemical, hematological and histopathological analysis between M. brumae and BCG-infected mice, as well as survival curves rates and colony forming units (CFU) counts in both animal models. M. brumae constitutes a safe therapeutic biological agent, overcoming the safety and toxicity disadvantages presented by BCG in both mice and G. mellonella animal models.
Note: Reproducció del document publicat a: https://doi.org/10.3390/vaccines8020198
It is part of: Vaccines, 2020, vol. 8(2), num. 198
URI: http://hdl.handle.net/2445/174370
Related resource: https://doi.org/10.3390/vaccines8020198
ISSN: 2076-393X
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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