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http://hdl.handle.net/2445/174374
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DC Field | Value | Language |
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dc.contributor.author | Ribera, Josep Maria | - |
dc.contributor.author | Morgades, Mireia | - |
dc.contributor.author | Montesinos, Pau | - |
dc.contributor.author | Tormo, Mar | - |
dc.contributor.author | Martínez Carballeira, Daniel | - |
dc.contributor.author | González Campos, José | - |
dc.contributor.author | Gil, Cristina | - |
dc.contributor.author | Barba, Pere | - |
dc.contributor.author | García Boyero, Raimundo | - |
dc.contributor.author | Coll, Rosa | - |
dc.contributor.author | Pedreño, María | - |
dc.contributor.author | Ribera, Jordi | - |
dc.contributor.author | Mercadal, Santiago | - |
dc.contributor.author | Vives, Susana | - |
dc.contributor.author | Novo, Andrés | - |
dc.contributor.author | Genescà, Eulàlia | - |
dc.contributor.author | Hernández Rivas, Jesús María | - |
dc.contributor.author | Bergua, Juan | - |
dc.contributor.author | Amigo, María Luz | - |
dc.contributor.author | Vall Llovera, Ferran | - |
dc.contributor.author | Martínez Sánchez, Pilar | - |
dc.contributor.author | Calbacho, María | - |
dc.contributor.author | García Cadenas, Irene | - |
dc.contributor.author | Garcia Guiñon, Antonio | - |
dc.contributor.author | Sánchez Sánchez, María José | - |
dc.contributor.author | Cervera, Marta | - |
dc.contributor.author | Feliu, Evarist | - |
dc.contributor.author | Orfao, Alberto | - |
dc.contributor.author | PETHEMA Group | - |
dc.date.accessioned | 2021-02-26T08:54:27Z | - |
dc.date.available | 2021-02-26T08:54:27Z | - |
dc.date.issued | 2020-04-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174374 | - |
dc.description.abstract | Background: Pediatric-based or -inspired trials have improved the prognosis of adolescents and young adults (AYA) with Philadelphia chromosome-negative (Ph-neg) acute lymphoblastic leukemia (ALL). Methods: This study reports the results of treatment of the ALLRE08 trial, a full pediatric trial for AYA aged 15-30 years with standard-risk (SR) ALL. Results: From 2008 to 2018, 89 patients (38 adolescents [15-18 years] and 51 young adults [YA, 19-30 years], median age: 20 [15-29] years) were enrolled in the ALLRE08 trial. The complete response (CR) was 95%. Twenty-two patients were transferred to a high-risk (HR) protocol because of poor marrow response on day 14 (n = 20) or high-level of end-induction minimal residual response (MRD ≥ 0.25%, n = 2). Cumulative incidence of relapse (CIR) at 5 years was 35% (95%CI: 23%-47%), with significant differences between adolescents and YA: 13% (4%-28%) vs 52% (34%-67%), P = .012. No treatment-related mortality was observed in 66/66 patients following the ALLRE08 trial vs 3/23 patients moved to a HR trial. The estimated 5-year overall survival (OS) was 74% (95%CI: 63%-85%), with significantly higher rates for adolescents vs YA: 87% (95%CI: 74%-100%) vs 63% (46%-80%), P = .021. Although CIR or OS were lower in patients who were transferred to a HR trial, the differences were not statistically significant (CIR: 34% [21%-47%] vs 37% [14%-61%]; OS: 78% [66%-90%] vs 61% [31%;91%]). Conclusion: A full pediatric trial is feasible and effective for AYA with Ph-neg, SR-ALL, with better results for adolescents than for YA. Outcome of patients with poor early response rescued with a HR trial was not significantly inferior. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/cam4.2814 | - |
dc.relation.ispartof | Cancer Medicine, 2020, vol. 9, num. 7, p. 2317-2329 | - |
dc.relation.uri | https://doi.org/10.1002/cam4.2814 | - |
dc.rights | cc by (c) Ribera et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Leucèmia limfocítica crònica | - |
dc.subject.classification | Adolescents | - |
dc.subject.other | Chronic lymphocytic leukemia | - |
dc.subject.other | Teenagers | - |
dc.title | A pediatric regimen for adolescents and young adults with Philadelphia chromosome‐negative acute lymphoblastic leukemia: Results of the ALLRE08 PETHEMA trial | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-02-16T12:17:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32022463 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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cam4.2814.pdf | 567.92 kB | Adobe PDF | View/Open |
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