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http://hdl.handle.net/2445/174434
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DC Field | Value | Language |
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dc.contributor.author | Linares Galiana, Isabel | - |
dc.contributor.author | Berenguer Francés, Miguel Ángel | - |
dc.contributor.author | Cañas Cortés, Rut | - |
dc.contributor.author | Pujol Canadell, Monica | - |
dc.contributor.author | Comas Antón, Silvia | - |
dc.contributor.author | Martínez, Evelyn | - |
dc.contributor.author | Laplana, Maria | - |
dc.contributor.author | Pérez Montero, Héctor | - |
dc.contributor.author | Pla Farnós, María Jesús | - |
dc.contributor.author | Navarro Martin, Arturo | - |
dc.contributor.author | Nuñez, Miriam | - |
dc.contributor.author | Both, Brigitte | - |
dc.contributor.author | Guedea Edo, Ferran | - |
dc.date.accessioned | 2021-03-01T08:57:50Z | - |
dc.date.available | 2021-03-01T08:57:50Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0449-3060 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174434 | - |
dc.description.abstract | A detailed understanding of the interactions and the best dose-fractionation scheme of radiation to maximize antitumor immunity have not been fully established. In this study, the effect on the host immune system of a single dose of 20 Gy through intraoperative radiation therapy (IORT) on the surgical bed in low-risk breast cancer patients undergoing conserving breast cancer has been assessed. Peripheral blood samples from 13 patients were collected preoperatively and at 48 h and 3 and 10 weeks after the administration of radiation. We performed a flow cytometry analysis for lymphocyte subpopulations, natural killer cells (NK), regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs). We observed that the subpopulation of NK CD56+high CD16+ increased significantly at 3 weeks after IORT (0.30-0.42%, P < 0.001), while no changes were found in immunosuppressive profile, CD4+CD25+Foxp3+Helios+ Treg cells, granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (Mo-MDSCs). A single dose of IORT may be an effective approach to improve antitumor immunity based on the increase in NK cells and the non-stimulation of immunosuppressive cells involved in immune escape. These findings support future combinations of IORT with immunotherapy, if they are confirmed in a large cohort of breast cancer patients. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/jrr/rraa083 | - |
dc.relation.ispartof | Journal of Radiation Research, 2021, vol. 62, num. 1, p. 110-118 | - |
dc.relation.uri | https://doi.org/10.1093/jrr/rraa083 | - |
dc.rights | cc-by (c) Linares Galiana, Isabel et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Radioteràpia | - |
dc.subject.classification | Immunoteràpia | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Radiotherapy | - |
dc.subject.other | Immunotheraphy | - |
dc.title | Changes in peripheral immune cells after intraoperative radiation therapy in low-risk breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 707070 | - |
dc.date.updated | 2021-03-01T08:57:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33006364 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
Files in This Item:
File | Description | Size | Format | |
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707070.pdf | 1.37 MB | Adobe PDF | View/Open |
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