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http://hdl.handle.net/2445/174530
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DC Field | Value | Language |
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dc.contributor.author | Munn-Chernoff, Melissa A. | - |
dc.contributor.author | Johnson, Emma C. | - |
dc.contributor.author | Chou, Yi Ling | - |
dc.contributor.author | Coleman, Jonathan R. I. | - |
dc.contributor.author | Thornton, Laura M. | - |
dc.contributor.author | Walters, Raymond K. | - |
dc.contributor.author | Yilmaz, Zeynep | - |
dc.contributor.author | Baker, Jessica H. | - |
dc.contributor.author | Hübel, Christopher | - |
dc.contributor.author | Gordon, Scott | - |
dc.contributor.author | Medland, Sarah E. | - |
dc.contributor.author | Luykx, Jurjen | - |
dc.contributor.author | Batzler, Anthony | - |
dc.contributor.author | McClintick, Jeanette N. | - |
dc.contributor.author | Slachtova, Lenka | - |
dc.contributor.author | Gonidakis, Fragiskos | - |
dc.contributor.author | Fichter, Manfred M. | - |
dc.contributor.author | Santonastaso, Paolo | - |
dc.contributor.author | Maes, Hermine H. | - |
dc.contributor.author | Pedersen, Nancy L. | - |
dc.contributor.author | Scherer, Stephen W. | - |
dc.contributor.author | Männistö, Satu | - |
dc.contributor.author | Shen, Pei-Hong | - |
dc.contributor.author | Mattheisen, Manuel | - |
dc.contributor.author | Hack, Laura M. | - |
dc.contributor.author | Rabionet Janssen, Raquel | - |
dc.contributor.author | Mullan Harris, Kathleen | - |
dc.contributor.author | Johnson, Eric O. | - |
dc.contributor.author | Tyszkiewicz-Nwafor, Marta | - |
dc.contributor.author | Crowley, James J. | - |
dc.contributor.author | Hottenga, Jouke Jan | - |
dc.contributor.author | Palotie, Aarno | - |
dc.contributor.author | Karwautz, Andreas | - |
dc.contributor.author | Witt, Stephanie H. | - |
dc.contributor.author | McGuffin, Peter | - |
dc.contributor.author | Giusti Rodríguez, Paola | - |
dc.contributor.author | Ramoz, Nicolas | - |
dc.contributor.author | Lahti Pulkkinen, Marius | - |
dc.contributor.author | Tarter, Ralph E. | - |
dc.contributor.author | Mannik, Katrin | - |
dc.contributor.author | Ophoff, Roel A. | - |
dc.contributor.author | Karpyak, Victor M. | - |
dc.contributor.author | Culverhouse, Robert C. | - |
dc.contributor.author | Papezova, Hana | - |
dc.contributor.author | Penninx, Brenda W. J. H. | - |
dc.contributor.author | Werge, Thomas | - |
dc.contributor.author | Dong, Li | - |
dc.contributor.author | Meulenbelt, Ingrid | - |
dc.contributor.author | Kalsi, Gursharan | - |
dc.contributor.author | La Via, Maria C. | - |
dc.contributor.author | Zerwas, Stephanie | - |
dc.contributor.author | Strober, Michael | - |
dc.contributor.author | Giegling, Ina | - |
dc.contributor.author | Palviainen, Teemu | - |
dc.contributor.author | McQueen, Matthew B. | - |
dc.contributor.author | Lissowska, Jolanta | - |
dc.contributor.author | Copeland, William E. | - |
dc.contributor.author | Edwards, Alexis C. | - |
dc.contributor.author | Danner, Unna N. | - |
dc.contributor.author | Magnusson, Patrik K. E. | - |
dc.contributor.author | Meyers, Jacquelyn L. | - |
dc.contributor.author | Szatkiewicz, Jin P. | - |
dc.contributor.author | Brandt, Harry | - |
dc.contributor.author | Kim, Youl R. | - |
dc.contributor.author | Preuss, Ulrich | - |
dc.contributor.author | Nurnberger, John I | - |
dc.contributor.author | Boraska Perica, Vesna | - |
dc.contributor.author | Hayward, Caroline | - |
dc.contributor.author | Gelernter, Joel | - |
dc.contributor.author | Dina, Christian | - |
dc.contributor.author | Forzan, Monica | - |
dc.contributor.author | Martin, Nicholas G. | - |
dc.contributor.author | Iacono, William G. | - |
dc.contributor.author | Foo, Jerome C. | - |
dc.contributor.author | Degenhardt, Louisa | - |
dc.contributor.author | Docampo, Elisa | - |
dc.contributor.author | Lind, Penelope A. | - |
dc.contributor.author | Zhou, Hang | - |
dc.contributor.author | Wetherill, Leah | - |
dc.contributor.author | Cichon, Sven | - |
dc.contributor.author | Clementi, Maurizio | - |
dc.contributor.author | Scherbaum, Norbert | - |
dc.contributor.author | Duncan, Laramie E. | - |
dc.contributor.author | Monteleone, Alessio Maria | - |
dc.contributor.author | Alfredsson, Lars | - |
dc.contributor.author | Schork, Nicholas J. | - |
dc.contributor.author | Hodgkinson, Colin | - |
dc.contributor.author | Schwandt, Melanie | - |
dc.contributor.author | Foroud, Tatiana M. | - |
dc.contributor.author | Danae Lin, Bochao | - |
dc.contributor.author | Kas, Martien J.H. | - |
dc.contributor.author | Choi, Doo-Sup | - |
dc.contributor.author | Ritschel, Franziska | - |
dc.contributor.author | Schosser, Alexandra | - |
dc.contributor.author | Ntalla, Ioanna | - |
dc.contributor.author | Kramer, John | - |
dc.contributor.author | Ising, Marcus | - |
dc.contributor.author | Fischer, Krista | - |
dc.contributor.author | Kaminská, Deborah | - |
dc.contributor.author | Gallinger, Steven | - |
dc.contributor.author | Ridinger, Monika | - |
dc.contributor.author | Horwood, L. John | - |
dc.contributor.author | Jordan, Jennifer | - |
dc.contributor.author | Riley, Brien P. | - |
dc.contributor.author | Biernacka, Joanna M. | - |
dc.contributor.author | Goldman, David | - |
dc.contributor.author | Hinney, Anke | - |
dc.contributor.author | Widen, Elisabeth | - |
dc.contributor.author | Wills, Amanda G. | - |
dc.contributor.author | Bacanu, Silviu Alin | - |
dc.contributor.author | Slof-Op't Landt, Margarita C. T. | - |
dc.contributor.author | Brown, Sandra A. | - |
dc.contributor.author | McIntosh, Andrew M. | - |
dc.contributor.author | Föcker, Manuel | - |
dc.contributor.author | Hauser, Joanna | - |
dc.contributor.author | Ehrlich, Stefan | - |
dc.contributor.author | Clarke, Toni-Kim | - |
dc.contributor.author | Kaplan, Allan S. | - |
dc.contributor.author | Hancock, Dana B. | - |
dc.contributor.author | Hopfer, Christian J. | - |
dc.contributor.author | Foretova, Lenka | - |
dc.contributor.author | Schosser, Jochen | - |
dc.contributor.author | Degenhardt, Franziska | - |
dc.contributor.author | Adkins, Daniel E. | - |
dc.contributor.author | Slopien, Agnieszka | - |
dc.contributor.author | Zhao, Hongyu | - |
dc.contributor.author | Burghardt, Roland | - |
dc.contributor.author | Adkins, Amy E. | - |
dc.contributor.author | Mann, Karl | - |
dc.contributor.author | Tortorella, Alfonso | - |
dc.contributor.author | Tziouvas, Konstantinos | - |
dc.contributor.author | Marshall, Christian R. | - |
dc.contributor.author | Thomas, Nathaniel | - |
dc.contributor.author | Klump, Kelly L. | - |
dc.contributor.author | Vanyukov, Michael M. | - |
dc.contributor.author | Lucae, Susanne | - |
dc.contributor.author | Boehm, Ilka | - |
dc.contributor.author | Henders, Anjali K. | - |
dc.contributor.author | Wang, Jen-Chyong | - |
dc.contributor.author | Tozzi, Federica | - |
dc.contributor.author | Bigdeli, Tim B. | - |
dc.contributor.author | Parker, Richard | - |
dc.contributor.author | Larsen, Janne T. | - |
dc.contributor.author | Marsal, Sara | - |
dc.contributor.author | Bo Mortensen, Preben | - |
dc.contributor.author | Crow, Scott | - |
dc.contributor.author | Mitchell, Karen | - |
dc.contributor.author | Ligthart, Lannie | - |
dc.contributor.author | Giuranna, Johanna | - |
dc.contributor.author | Janout, Vladimir | - |
dc.contributor.author | Heilmann Heimbach, Stefanie | - |
dc.contributor.author | Kiefer, Falk | - |
dc.contributor.author | Imgart, Hartmut | - |
dc.contributor.author | Landén, Mikael | - |
dc.contributor.author | DeSocio, Janiece E. | - |
dc.contributor.author | Edenberg, Howard J. | - |
dc.contributor.author | Soyka, Michael | - |
dc.contributor.author | Walton, Esther | - |
dc.contributor.author | Jiménez-Murcia, Susana | - |
dc.contributor.author | Davis, Oliver S. P. | - |
dc.contributor.author | Micali, Nadia | - |
dc.contributor.author | Müller Myhsok, Bertram | - |
dc.contributor.author | Hellard, Stephanie Le | - |
dc.contributor.author | Keski Rahkonen, Anna | - |
dc.contributor.author | Mattingsdal, Morten | - |
dc.contributor.author | Sullivan, Patrick F. | - |
dc.contributor.author | Rietschel, Marcella | - |
dc.contributor.author | Dikeos, Dimitris | - |
dc.contributor.author | Hartmann, Annette M. | - |
dc.contributor.author | Lahti, Jari | - |
dc.contributor.author | Webb, Bradley T. | - |
dc.contributor.author | Hudson, James I. | - |
dc.contributor.author | Diazgranados, Nancy | - |
dc.contributor.author | Karhunen, Leila | - |
dc.contributor.author | Sorbi, Sandro | - |
dc.contributor.author | Domingue, Benjamin W. | - |
dc.contributor.author | Hebebrand, Johannes | - |
dc.contributor.author | Gratacos Mayora, Monica | - |
dc.contributor.author | Cone, Roger D. | - |
dc.contributor.author | Andreassen, Ole A. | - |
dc.contributor.author | Dedoussis, George | - |
dc.contributor.author | Krauter, Kenneth | - |
dc.contributor.author | Estivill, Xavier, 1955- | - |
dc.contributor.author | Costello, E. Jane | - |
dc.contributor.author | Guillaume, Sébastien | - |
dc.contributor.author | Navratilova, Marie | - |
dc.contributor.author | Rose, Richard J. | - |
dc.contributor.author | Leppä, Virpi M. | - |
dc.contributor.author | Sanchez Roige, Sandra | - |
dc.contributor.author | Kennedy, James L. | - |
dc.contributor.author | Rybakowski, Filip | - |
dc.contributor.author | Whitfield, John B. | - |
dc.contributor.author | Tsitsika, Artemis | - |
dc.contributor.author | Crawford, Steven | - |
dc.contributor.author | Treutlein, Jens | - |
dc.contributor.author | Keyes, Margaret | - |
dc.contributor.author | Świątkowska, Beata | - |
dc.contributor.author | Heath, Andrew C. | - |
dc.contributor.author | Zeggini, Eleftheria | - |
dc.contributor.author | Treasure, Janet | - |
dc.contributor.author | Monteleone, Palmiero | - |
dc.contributor.author | Vrieze, Scott | - |
dc.contributor.author | Pearson, John F. | - |
dc.contributor.author | McGue, Matt | - |
dc.contributor.author | Nöthen, Markus M. | - |
dc.contributor.author | Bergen, Andrew W. | - |
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dc.contributor.author | Herms, Stefan | - |
dc.contributor.author | Ricca, Valdo | - |
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dc.contributor.author | Padyukov, Leonid | - |
dc.contributor.author | Guo, Yiran | - |
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dc.contributor.author | Dongbing, Lai | - |
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dc.contributor.author | Schuckit, Marc A. | - |
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dc.contributor.author | Loukola, Anu | - |
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dc.contributor.author | Rujescu, Dan | - |
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dc.contributor.author | Hatzikotoulas, Konstantinos | - |
dc.contributor.author | Kendler, Kenneth S. | - |
dc.contributor.author | Saccone, Nancy L. | - |
dc.contributor.author | Johnson, Craig | - |
dc.contributor.author | Dmitrzak Weglarz, Monika | - |
dc.contributor.author | Zipfel, Stephan | - |
dc.contributor.author | Hanscombe, Ken B. | - |
dc.contributor.author | Agrawal, Arpana | - |
dc.contributor.author | Roberts, Marion | - |
dc.contributor.author | Pinto, Dalila | - |
dc.contributor.author | Peterson, Roseann E. | - |
dc.contributor.author | Gaspar, Héléna A. | - |
dc.contributor.author | Reynolds, Maureen D. | - |
dc.contributor.author | Breen, Gerome | - |
dc.contributor.author | Gillespie, Nathan A. | - |
dc.contributor.author | Boni, Claudette | - |
dc.contributor.author | Hakonarson, Hakon | - |
dc.contributor.author | Fox, Louis | - |
dc.contributor.author | Rotondo, Alessandro | - |
dc.contributor.author | Escaramís Babiano, Geòrgia | - |
dc.contributor.author | Forstner, Andreas J. | - |
dc.contributor.author | Van Furth, Eric F. | - |
dc.contributor.author | Salvatore, Jessica E. | - |
dc.contributor.author | Porjesz, Bernice | - |
dc.contributor.author | Berrettini, Wade H. | - |
dc.contributor.author | Boomsma, Dorret I. | - |
dc.contributor.author | Koller, Gabriele | - |
dc.contributor.author | Wedow, Robbee | - |
dc.contributor.author | Frank, Josef | - |
dc.contributor.author | Ripatti, Samuli | - |
dc.contributor.author | Magistretti, Pierre J. | - |
dc.contributor.author | Polimanti, Renato | - |
dc.contributor.author | Schmidt, Ulrike | - |
dc.contributor.author | Zwaan, Martina de | - |
dc.contributor.author | Boden, Joseph M. | - |
dc.contributor.author | Zill, Peter | - |
dc.contributor.author | Mitchell, James | - |
dc.contributor.author | Ryu, Euijung | - |
dc.contributor.author | Scherag, André | - |
dc.contributor.author | MacKillop, James | - |
dc.contributor.author | Mbarek, Hamdi | - |
dc.contributor.author | Herpertz-Dahlmann, Beate | - |
dc.contributor.author | Hesselbrock, Victor | - |
dc.contributor.author | Dahmen, Norbert | - |
dc.contributor.author | Lilenfeld, Lisa | - |
dc.contributor.author | Silberg, Judy | - |
dc.date.accessioned | 2021-03-01T20:08:37Z | - |
dc.date.available | 2021-03-01T20:08:37Z | - |
dc.date.issued | 2020-02-16 | - |
dc.identifier.issn | 1355-6215 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174530 | - |
dc.description.abstract | Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1111/adb.12880 | - |
dc.relation.ispartof | Addiction Biology, 2020, vol. 26(1), num. e12880 | - |
dc.relation.uri | https://doi.org/10.1111/adb.12880 | - |
dc.rights | (c) Society for the Study of Addiction, 2020 | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Trastorns de la conducta alimentària | - |
dc.subject.classification | Genètica | - |
dc.subject.classification | Factors de risc en les malalties | - |
dc.subject.classification | Fenotip | - |
dc.subject.classification | Consum d'alcohol | - |
dc.subject.classification | Abús de substàncies | - |
dc.subject.other | Eating disorders | - |
dc.subject.other | Genetics | - |
dc.subject.other | Risk factors in diseases | - |
dc.subject.other | Phenotype | - |
dc.subject.other | Drinking of alcoholic beverages | - |
dc.subject.other | Substance abuse | - |
dc.title | Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 700027 | - |
dc.date.updated | 2021-03-01T20:08:38Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/669026/EU//BIORISE | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32064741 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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700027.pdf | 496.81 kB | Adobe PDF | View/Open |
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