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Title: Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome
Author: Bittner, Vera A.
Szarek, Michael
Aylward, Philip E.
Bhatt, Deepak L.
Diaz, Rafael
Edelberg, Jay M.
Fras, Zlatko
Goodman, Shaun G.
Halvorsen, Sigrun
Hanotin, Corinne
Harrington, Robert A.
Jukema, J. Wouter
Loizeau, Virginie
Moriarty, Patrick M.
Moryusef, Angèle
Pordy, Robert
Roe, Matthew T.
Sinnaeve, Peter
Tsimikas, Sotirios
Vogel, Robert
White, Harvey D.
Zahger, Doron
Zeiher, Andreas M.
Steg, Ph. Gabriel
Schwartz, Gregory G.
ODYSSEY OUTCOMES Committees and Investigators
Keywords: Malalties cardiovasculars
Malalties del cor
Factors de risc en les malalties
Heart diseases
Cardiovascular diseases
Risk factors in diseases
Issue Date: 1-Jan-2020
Publisher: Elsevier BV
Abstract: Background: Lipoprotein(a) concentration is associated with cardiovascular events. Alirocumab, a proprotein convertase subtilisin/kexin type 9 inhibitor, lowers lipoprotein(a) and low-density lipoprotein cholesterol (LDL-C). Objectives: A pre-specified analysis of the placebo-controlled ODYSSEY Outcomes trial in patients with recent acute coronary syndrome (ACS) determined whether alirocumab-induced changes in lipoprotein(a) and LDL-C independently predicted major adverse cardiovascular events (MACE). Methods: One to 12 months after ACS, 18,924 patients on high-intensity statin therapy were randomized to alirocumab or placebo and followed for 2.8 years (median). Lipoprotein(a) was measured at randomization and 4 and 12 months thereafter. The primary MACE outcome was coronary heart disease death, nonfatal myocardial infarction, ischemic stroke, or hospitalization for unstable angina. Results: Baseline lipoprotein(a) levels (median: 21.2 mg/dl; interquartile range [IQR]: 6.7 to 59.6 mg/dl) and LDL-C [corrected for cholesterol content in lipoprotein(a)] predicted MACE. Alirocumab reduced lipoprotein(a) by 5.0 mg/dl (IQR: 0 to 13.5 mg/dl), corrected LDL-C by 51.1 mg/dl (IQR: 33.7 to 67.2 mg/dl), and reduced the risk of MACE (hazard ratio [HR]: 0.85; 95% confidence interval [CI]: 0.78 to 0.93). Alirocumab-induced reductions of lipoprotein(a) and corrected LDL-C independently predicted lower risk of MACE, after adjustment for baseline concentrations of both lipoproteins and demographic and clinical characteristics. A 1-mg/dl reduction in lipoprotein(a) with alirocumab was associated with a HR of 0.994 (95% CI: 0.990 to 0.999; p = 0.0081). Conclusions: Baseline lipoprotein(a) and corrected LDL-C levels and their reductions by alirocumab predicted the risk of MACE after recent ACS. Lipoprotein(a) lowering by alirocumab is an independent contributor to MACE reduction, which suggests that lipoprotein(a) should be an independent treatment target after ACS. (ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab; NCT01663402).
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It is part of: Journal of the American College of Cardiology, 2020, vol. 75, issue. 2, p. 133-144
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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