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http://hdl.handle.net/2445/174779
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DC Field | Value | Language |
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dc.contributor.author | Reed, Catherine | - |
dc.contributor.author | Belger, Mark | - |
dc.contributor.author | Scott Andrews, J. Scott | - |
dc.contributor.author | Tockhorn Heidenreich, Antje | - |
dc.contributor.author | Jones, Roy W. | - |
dc.contributor.author | Wimo, Anders | - |
dc.contributor.author | Dodel, Richard | - |
dc.contributor.author | Haro Abad, Josep Maria | - |
dc.date.accessioned | 2021-03-08T15:06:50Z | - |
dc.date.available | 2021-03-08T15:06:50Z | - |
dc.date.issued | 2019-05-28 | - |
dc.identifier.issn | 1041-6102 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174779 | - |
dc.description.abstract | OBJECTIVE: To identify, in caregivers of patients with Alzheimer's disease (AD) dementia, factors associated with subjective (personal, physical, emotional, and social) and objective (informal caregiver time and costs) caregiver burden. DESIGN: Prospective longitudinal European observational study: post-hoc analysis. SETTING: Clinic. PARTICIPANTS: Community-dwelling patients in France and Germany aged ≥ 55 years (n = 969) with probable AD and their informal caregivers. MEASUREMENTS: Mini-Mental State Examination (MMSE), Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADCS-ADL), 12-item Neuropsychiatric Inventory (NPI-12), Zarit Burden Interview (ZBI), informal caregiver basic and instrumental ADL hours (Resource Utilization in Dementia instrument), and informal caregiver costs. Mixed-effect models of repeated measures (MMRM) were run, including baseline and time-dependent covariates (change from baseline [CFB] to 18 months in MMSE, ADCS-ADL, and NPI-12 scores) associated with CFB in ZBI score/informal caregiver time over 36 months (analyzed using linear regression models) and informal caregiver costs over 36 months (analyzed using generalized linear models). RESULTS: Greater decline in patient function (ADCS-ADL) over 18 months was associated with increased subjective caregiver burden (ZBI), hours, and costs over 36 months. Increased behavioral problems (NPI-12) over 18 months also negatively impacted ZBI. Cognitive decline (MMSE) over 18 months did not affect change in caregiver burden. CONCLUSIONS: Long-term informal caregiver burden was driven by worsening functional abilities and behavioral symptoms but not cognitive decline, over 18 months in community-dwelling patients with AD dementia. Identifying the drivers of caregiver burden could highlight areas in which interventions may benefit both caregivers and patients. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1017/S1041610219000425 | - |
dc.relation.ispartof | International Psychogeriatrics, 2019, vol. 32, num. 2, p. 267-277 | - |
dc.relation.uri | https://doi.org/10.1017/S1041610219000425 | - |
dc.rights | (c) cc-by Reed et. al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Cuidadors | - |
dc.subject.classification | Investigació mèdica | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Caregivers | - |
dc.subject.other | Medicine research | - |
dc.title | Factors associated with long-term impact on informal caregivers during Alzheimer's disease dementia progression: 36-month results from GERAS | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 699618 | - |
dc.date.updated | 2021-03-08T15:06:51Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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699618.pdf | 488.86 kB | Adobe PDF | View/Open |
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