Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/174793
Title: Drosophila ClC-a is required in glia of the stem cell niche for proper neurogenesis and wiring of neural circuits
Author: Plazaola Sasieta, Haritz
Zhu, Qi
Gaitán Peñas, Héctor
Rios, Martín
Estévez Povedano, Raúl
Morey, Marta
Keywords: Cèl·lules mare
Malalties neurodegeneratives
Teixit nerviós
Stem cells
Neurodegenerative Diseases
Nerve tissue
Issue Date: 3-Sep-2019
Publisher: Wiley
Abstract: Glial cells form part of the neural stem cell niche and express a wide variety of ion channels; however, the contribution of these channels to nervous system develop ment is poorly understood. We explored the function of the Drosophila ClC-a chloride channel, since its mammalian ortholog CLCN2 is expressed in glial cells, and defective channel function results in leukodystrophies, which in humans are accompanied by cognitive impairment. We found that ClC-a was expressed in the niche in cortex glia, which are closely associated with neurogenic tissues. Characterization of loss-of function ClC-a mutants revealed that these animals had smaller brains and widespread wiring defects. We showed that ClC-a is required in cortex glia for neurogenesis in neuroepithelia and neuroblasts, and identified defects in a neuroblast lineage that generates guidepost glial cells essential for photoreceptor axon guidance. We propose that glia-mediated ionic homeostasis could nonautonomously affect neurogenesis, and consequently, the correct assembly of neural circuits.
Note: Reproducció del document publicat a: https://doi.org/10.1002/glia.23691
It is part of: Glia, 2019, vol. 67, num. 12, p. 2374-2398
URI: http://hdl.handle.net/2445/174793
Related resource: https://doi.org/10.1002/glia.23691
ISSN: 0894-1491
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Ciències Fisiològiques)
Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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