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http://hdl.handle.net/2445/174855
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DC Field | Value | Language |
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dc.contributor.author | Urdinguio, Rocío G. | - |
dc.contributor.author | Lopez, Virginia | - |
dc.contributor.author | Bayón, Gustavo F. | - |
dc.contributor.author | Diaz de la guardia, Rafael | - |
dc.contributor.author | Sierra, Marta I. | - |
dc.contributor.author | García Toraño, Estela | - |
dc.contributor.author | Perez, Raúl F. | - |
dc.contributor.author | García, María G. | - |
dc.contributor.author | Carella, Antonella | - |
dc.contributor.author | Pruneda, Patricia C. | - |
dc.contributor.author | Prieto, Cristina | - |
dc.contributor.author | Dmitrijeva, Marija | - |
dc.contributor.author | Santamarina, Pablo | - |
dc.contributor.author | Belmonte, Thalía | - |
dc.contributor.author | Mangas, Cristina | - |
dc.contributor.author | Diaconu, Elena | - |
dc.contributor.author | Ferrero, Cecilia | - |
dc.contributor.author | Tejedor, Juan Ramón | - |
dc.contributor.author | Fernandez Morera, Juan Luis | - |
dc.contributor.author | Bravo, Cristina | - |
dc.contributor.author | Bueno, Clara | - |
dc.contributor.author | Sanjuan Pla, Alejandra | - |
dc.contributor.author | Rodriguez, Ramon M. | - |
dc.contributor.author | Suarez Alvarez, Beatriz | - |
dc.contributor.author | López Larrea, Carlos | - |
dc.contributor.author | Bernal, Teresa | - |
dc.contributor.author | Colado, Enrique | - |
dc.contributor.author | Balbín, Milagros | - |
dc.contributor.author | García Suarez, Olivia | - |
dc.contributor.author | Chiara, María Dolores | - |
dc.contributor.author | Sáenz de Santa María, Inés | - |
dc.contributor.author | Rodríguez, Francisco | - |
dc.contributor.author | Pando Sandoval, Ana | - |
dc.contributor.author | Rodrigo, Luis | - |
dc.contributor.author | Santos, Laura | - |
dc.contributor.author | Salas, Anna | - |
dc.contributor.author | Vallejo Díaz, Jesús | - |
dc.contributor.author | Carrera, Ana C. | - |
dc.contributor.author | Rico, Daniel | - |
dc.contributor.author | Hernández López, Inmaculada | - |
dc.contributor.author | Vayá, Amparo | - |
dc.contributor.author | Ricart, Josep M. | - |
dc.contributor.author | Seto, Edward | - |
dc.contributor.author | Sima Teruel, Núria | - |
dc.contributor.author | Vaquero García, Alejandro | - |
dc.contributor.author | Valledor, Luis | - |
dc.contributor.author | Cañal, Maria Jesus | - |
dc.contributor.author | Pisano, David | - |
dc.contributor.author | Graña Castro, Osvaldo | - |
dc.contributor.author | Thomas, Tim | - |
dc.contributor.author | Voss, Anne K. | - |
dc.contributor.author | Menéndez, Pablo | - |
dc.contributor.author | Villar Garea, Ana | - |
dc.contributor.author | Deutzmann, Rainer | - |
dc.contributor.author | Fernandez, Agustín F. | - |
dc.contributor.author | Fraga, Mario F. | - |
dc.date.accessioned | 2021-03-09T19:26:00Z | - |
dc.date.available | 2021-03-09T19:26:00Z | - |
dc.date.issued | 2019-03-29 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174855 | - |
dc.description.abstract | Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkz195 | - |
dc.relation.ispartof | Nucleic Acids Research, 2019, vol. 47, num. 10, p. 5016-5037 | - |
dc.relation.uri | https://doi.org/10.1093/nar/gkz195 | - |
dc.rights | cc by-nc (c) Urdinguio et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Cromatina | - |
dc.subject.classification | Mort cel·lular | - |
dc.subject.other | Chromatin | - |
dc.subject.other | Cell death | - |
dc.title | Chromatin regulation by Histone H4 acetylation at Lysine 16 during cell death and differentiation in the myeloid compartment | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-03-09T08:15:57Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/646903/EU//INFANTLEUKEMIA | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30923829 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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gkz195.pdf | 5.36 MB | Adobe PDF | View/Open |
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