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http://hdl.handle.net/2445/174895
Title: | Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease |
Author: | Griñán Ferré, Christian Codony Gisbert, Sandra Pujol Bech, Eugènia Yang, Jun Leiva Martínez, Rosana Escolano Mirón, Carmen Puigoriol Illamola, Dolors Companys Alemany, Júlia Corpas Expósito, Rubén Sanfeliu i Pujol, Coral Pérez, Belén Loza, María Isabel Brea, José Morisseau, Christophe Hammock, Bruce D. Vázquez Cruz, Santiago Pallàs i Llibería, Mercè, 1964- Galdeano Cantador, Carlos |
Keywords: | Malaltia d'Alzheimer Inflamació Malalties neurodegeneratives Alzheimer's disease Inflammation Neurodegenerative Diseases |
Issue Date: | 2-Jun-2020 |
Publisher: | Springer Verlag |
Abstract: | The inhibition of the enzyme soluble epoxide hydrolase (sEH) has demonstrated clinical therapeutic effects in several peripheral inflammatory-related diseases, with three compounds in clinical trials. However, the role of this enzyme in the neuroinflammation process has been largely neglected. Herein, we disclose the pharmacological validation of sEH as a novel target for the treatment of Alzheimer's Disease (AD). Evaluation of cognitive impairment and pathological hallmarks were used in two models of age-related cognitive decline and AD using three structurally different and potent sEH inhibitors as chemical probes. sEH is upregulated in brains from AD patients. Our findings supported the beneficial effects of central sEH inhibition, regarding reducing cognitive impairment, neuroinflammation, tau hyperphosphorylation pathology and the number of amyloid plaques. This study suggests that inhibition of inflammation in the brain by targeting sEH is a relevant therapeutic strategy for AD. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1007/s13311-020-00854-1 |
It is part of: | Neurotherapeutics, 2020 |
URI: | http://hdl.handle.net/2445/174895 |
Related resource: | https://doi.org/10.1007/s13311-020-00854-1 |
ISSN: | 1933-7213 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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