Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/175067
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dc.contributor.authorBarbui, Tiziano-
dc.contributor.authorStefano, Valerio De-
dc.contributor.authorÁlvarez Larrán, Alberto-
dc.contributor.authorIurlo, Alessandra-
dc.contributor.authorMasciulli, Arianna-
dc.contributor.authorCarobbio, Alessandra-
dc.contributor.authorGhirardi, Arianna-
dc.contributor.authorFerrari, Alberto-
dc.contributor.authorCancelli, Valeria-
dc.contributor.authorElli, Elena Maria-
dc.contributor.authorAndrade Campos, Marcio Miguel-
dc.contributor.authorGasior Kabat, Mercedes-
dc.contributor.authorKiladjian, Jean-Jacques-
dc.contributor.authorPalandri, Francesca-
dc.contributor.authorBenevolo, Giulia-
dc.contributor.authorGarcia Gutierrez, Valentin-
dc.contributor.authorFox, Maria Laura-
dc.contributor.authorFoncillas, Maria Angeles-
dc.contributor.authorMorcillo, Carmen Montoya-
dc.contributor.authorRumi, Elisa-
dc.contributor.authorOsorio, Santiago-
dc.contributor.authorPapadopoulos, Petros-
dc.contributor.authorBonifacio, Massimiliano-
dc.contributor.authorQuiroz Cervantes, Keina Susana-
dc.contributor.authorSerrano, Miguel Sagues-
dc.contributor.authorCarreño Tarragona, Gonzalo-
dc.contributor.authorSobas, Marta Anna-
dc.contributor.authorLunghi, Francesca-
dc.contributor.authorPatriarca, Andrea-
dc.contributor.authorElorza, Begoña Navas-
dc.contributor.authorAngona, Anna-
dc.contributor.authorMazo, Elena Magro-
dc.contributor.authorKoschmieder, Steffen-
dc.contributor.authorCarli, Giuseppe-
dc.contributor.authorCuevas, Beatriz-
dc.contributor.authorHernandez Boluda, Juan Carlos-
dc.contributor.authorAbadia, Emma Lopez-
dc.contributor.authorXicoy Cirici, Blanca-
dc.contributor.authorGuglielmelli, Paola-
dc.contributor.authorGarrote, Marta-
dc.contributor.authorCattaneo, Daniele-
dc.contributor.authorDaffini, Rosa-
dc.contributor.authorCavalca, Fabrizio-
dc.contributor.authorBellosillo, Beatriz-
dc.contributor.authorBenajiba, Lina-
dc.contributor.authorCurto Garcia, Natalia-
dc.contributor.authorBellini, Marta-
dc.contributor.authorBetti, Silvia-
dc.contributor.authorHarrison, Claire-
dc.contributor.authorRambaldi, Alessandro-
dc.contributor.authorVannucchi, Alessandro Maria-
dc.date.accessioned2021-03-15T12:05:26Z-
dc.date.available2021-03-15T12:05:26Z-
dc.date.issued2021-02-01-
dc.identifier.urihttp://hdl.handle.net/2445/175067-
dc.description.abstractIn a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, n = 42), myelofibrosis (MF, n = 56), and prefibrotic myelofibrosis (pre-PMF, n = 16), 15 major thromboses (3 arterial and 12 venous) were registered in 14 patients, of whom all, but one, were receiving LMW-heparin prophylaxis. After adjustment for the competing risk of death, the cumulative incidence of arterial and venous thromboembolic events (VTE) reached 8.5% after 60 days follow-up. Of note, 8 of 12 VTE were seen in ET. Interestingly, at COVID-19 diagnosis, MPN patients had significantly lower platelet count (p < 0.0001) than in the pre-COVID last follow-up.This decline was remarkably higher in ET (-23.3%, p < 0.0001) than in PV (-16.4%, p = 0.1730) and was associated with higher mortality rate (p = 0.0010) for pneumonia. The effects of possible predictors of thrombosis, selected from those clinically relevant and statistically significant in univariate analysis, were examined in a multivariate model. Independent risk factors were transfer to ICU (SHR = 3.73, p = 0.029), neutrophil/lymphocyte ratio (SHR = 1.1, p = 0.001) and ET phenotype (SHR = 4.37, p = 0.006). The enhanced susceptibility to ET-associated VTE and the associated higher mortality for pneumonia may recognize a common biological plausibility and deserve to be delved to tailor new antithrombotic regimens including antiplatelet drugs.-
dc.format.extent11 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer Nature-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1038/s41408-021-00417-3-
dc.relation.ispartofBlood Cancer Journal, 2021, vol. 11-
dc.relation.urihttps://doi.org/10.1038/s41408-021-00417-3-
dc.rightscc by (c) Barbui et al., 2021-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))-
dc.subject.classificationLeucèmia mieloide-
dc.subject.classificationTrombosi-
dc.subject.classificationCOVID-19-
dc.subject.otherMyeloid leukemia-
dc.subject.otherThrombosis-
dc.subject.otherCOVID-19-
dc.titleAmong classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2021-03-11T11:57:40Z-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/945406/EU//HARMONY PLUS-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid33563901-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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