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DC Field | Value | Language |
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dc.contributor.author | Barbui, Tiziano | - |
dc.contributor.author | Stefano, Valerio De | - |
dc.contributor.author | Álvarez Larrán, Alberto | - |
dc.contributor.author | Iurlo, Alessandra | - |
dc.contributor.author | Masciulli, Arianna | - |
dc.contributor.author | Carobbio, Alessandra | - |
dc.contributor.author | Ghirardi, Arianna | - |
dc.contributor.author | Ferrari, Alberto | - |
dc.contributor.author | Cancelli, Valeria | - |
dc.contributor.author | Elli, Elena Maria | - |
dc.contributor.author | Andrade Campos, Marcio Miguel | - |
dc.contributor.author | Gasior Kabat, Mercedes | - |
dc.contributor.author | Kiladjian, Jean-Jacques | - |
dc.contributor.author | Palandri, Francesca | - |
dc.contributor.author | Benevolo, Giulia | - |
dc.contributor.author | Garcia Gutierrez, Valentin | - |
dc.contributor.author | Fox, Maria Laura | - |
dc.contributor.author | Foncillas, Maria Angeles | - |
dc.contributor.author | Morcillo, Carmen Montoya | - |
dc.contributor.author | Rumi, Elisa | - |
dc.contributor.author | Osorio, Santiago | - |
dc.contributor.author | Papadopoulos, Petros | - |
dc.contributor.author | Bonifacio, Massimiliano | - |
dc.contributor.author | Quiroz Cervantes, Keina Susana | - |
dc.contributor.author | Serrano, Miguel Sagues | - |
dc.contributor.author | Carreño Tarragona, Gonzalo | - |
dc.contributor.author | Sobas, Marta Anna | - |
dc.contributor.author | Lunghi, Francesca | - |
dc.contributor.author | Patriarca, Andrea | - |
dc.contributor.author | Elorza, Begoña Navas | - |
dc.contributor.author | Angona, Anna | - |
dc.contributor.author | Mazo, Elena Magro | - |
dc.contributor.author | Koschmieder, Steffen | - |
dc.contributor.author | Carli, Giuseppe | - |
dc.contributor.author | Cuevas, Beatriz | - |
dc.contributor.author | Hernandez Boluda, Juan Carlos | - |
dc.contributor.author | Abadia, Emma Lopez | - |
dc.contributor.author | Xicoy Cirici, Blanca | - |
dc.contributor.author | Guglielmelli, Paola | - |
dc.contributor.author | Garrote, Marta | - |
dc.contributor.author | Cattaneo, Daniele | - |
dc.contributor.author | Daffini, Rosa | - |
dc.contributor.author | Cavalca, Fabrizio | - |
dc.contributor.author | Bellosillo, Beatriz | - |
dc.contributor.author | Benajiba, Lina | - |
dc.contributor.author | Curto Garcia, Natalia | - |
dc.contributor.author | Bellini, Marta | - |
dc.contributor.author | Betti, Silvia | - |
dc.contributor.author | Harrison, Claire | - |
dc.contributor.author | Rambaldi, Alessandro | - |
dc.contributor.author | Vannucchi, Alessandro Maria | - |
dc.date.accessioned | 2021-03-15T12:05:26Z | - |
dc.date.available | 2021-03-15T12:05:26Z | - |
dc.date.issued | 2021-02-01 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175067 | - |
dc.description.abstract | In a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, n = 42), myelofibrosis (MF, n = 56), and prefibrotic myelofibrosis (pre-PMF, n = 16), 15 major thromboses (3 arterial and 12 venous) were registered in 14 patients, of whom all, but one, were receiving LMW-heparin prophylaxis. After adjustment for the competing risk of death, the cumulative incidence of arterial and venous thromboembolic events (VTE) reached 8.5% after 60 days follow-up. Of note, 8 of 12 VTE were seen in ET. Interestingly, at COVID-19 diagnosis, MPN patients had significantly lower platelet count (p < 0.0001) than in the pre-COVID last follow-up.This decline was remarkably higher in ET (-23.3%, p < 0.0001) than in PV (-16.4%, p = 0.1730) and was associated with higher mortality rate (p = 0.0010) for pneumonia. The effects of possible predictors of thrombosis, selected from those clinically relevant and statistically significant in univariate analysis, were examined in a multivariate model. Independent risk factors were transfer to ICU (SHR = 3.73, p = 0.029), neutrophil/lymphocyte ratio (SHR = 1.1, p = 0.001) and ET phenotype (SHR = 4.37, p = 0.006). The enhanced susceptibility to ET-associated VTE and the associated higher mortality for pneumonia may recognize a common biological plausibility and deserve to be delved to tailor new antithrombotic regimens including antiplatelet drugs. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41408-021-00417-3 | - |
dc.relation.ispartof | Blood Cancer Journal, 2021, vol. 11 | - |
dc.relation.uri | https://doi.org/10.1038/s41408-021-00417-3 | - |
dc.rights | cc by (c) Barbui et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Leucèmia mieloide | - |
dc.subject.classification | Trombosi | - |
dc.subject.classification | COVID-19 | - |
dc.subject.other | Myeloid leukemia | - |
dc.subject.other | Thrombosis | - |
dc.subject.other | COVID-19 | - |
dc.title | Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-03-11T11:57:40Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/945406/EU//HARMONY PLUS | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33563901 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41408-021-00417-3.pdf | 1.38 MB | Adobe PDF | View/Open |
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