Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/175091
Title: Lifetime alcohol intake, drinking patterns over time, and risk of stomach cancer: a pooled analysis of data from two prospective cohort studies
Author: Jayasekara, Harindra
Macinnis, Robert J.
Luján Barroso, Leila
Mayen Chacon, Ana Lucia
Cross, Amanda J.
Wallner, Bengt
Palli, Domenico
Ricceri, Fulvio
Pala, Valeria
Panico, Salvatore
Tumino, Rosario
Kühn, Tilman
Kaaks, Rudolf
Tsilidis, Kostas
Sánchez, María José
Amiano, Pilar
Ardanaz, Eva
Chirlaque, María Dolores
Merino, Susana
Rothwell, Joseph A.
Boutron-Ruault, Marie-Christine
Severi, Gianluca
Sternby, Hanna
Sonestedt, Emily
Bueno de Mesquita, H. Bas
Boeing, Heiner
Travis, Ruth
Sandanger, Torkjel M.
Trichopoulou, Antonia
Karakatsani, Anna
Peppa, Eleni
Tjønneland, Anne
Yang, Yi
Hodge, Allison M.
Mitchell, Hazel
Haydon, Andrew
Room, Robin
Hopper, John L.
Weiderpass, Elisabete
Gunter, Marc J.
Riboli, Elio
Giles, Graham G.
Milne, Roger L.
Agudo, Antonio
English, Dallas R.
Ferrari, Pietro
Keywords: Consum d'alcohol
Càncer d'estómac
Drinking of alcoholic beverages
Stomach cancer
Issue Date: 22-Feb-2021
Publisher: John Wiley & Sons Ltd.
Abstract: Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.
Note: Reproducció del document publicat a: https://doi.org/10.1002/ijc.33504
It is part of: International Journal of Cancer, 2021
URI: http://hdl.handle.net/2445/175091
Related resource: https://doi.org/10.1002/ijc.33504
Appears in Collections:Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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