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DC Field | Value | Language |
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dc.contributor.author | Mahé, Isabelle | - |
dc.contributor.author | Sterpu, Raluca | - |
dc.contributor.author | Bertoletti, Laurent | - |
dc.contributor.author | López Jiménez, Luciano | - |
dc.contributor.author | Mellado Joan, Meritxell | - |
dc.contributor.author | Trujillo Santos, Javier | - |
dc.contributor.author | Ballaz, Aitor | - |
dc.contributor.author | Hernández Blasco, Luis Manuel | - |
dc.contributor.author | Marchena, Pablo Javier | - |
dc.contributor.author | Monreal, Manuel | - |
dc.contributor.author | RIETE investigators | - |
dc.date.accessioned | 2021-03-16T11:46:31Z | - |
dc.date.available | 2021-03-16T11:46:31Z | - |
dc.date.issued | 2015-06-15 | - |
dc.identifier.issn | 1549-1277 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175184 | - |
dc.description.abstract | Current guidelines of antithrombotic therapy suggest early initiation of vitamin K antagonists (VKA) in non-cancer patients with venous thromboembolism (VTE), and long-term therapy with low-molecular weight heparin (LMWH) for those with cancer. We used data from RIETE (international registry of patients with VTE) to report the use of long-term anticoagulant therapy over time and to identify predictors of anticoagulant choice (regarding international guidelines) in patients with- and without cancer. Among 35,280 patients without cancer, 82% received long-term VKA (but 17% started after the first week). Among 4,378 patients with cancer, 66% received long term LMWH as monotherapy. In patients without cancer, recent bleeding (odds ratio [OR] 2.70, 95% CI 2.26-3.23), age >70 years (OR 1.15, 95% CI 1.06-1.24), immobility (OR 2.06, 95% CI 1.93-2.19), renal insufficiency (OR 2.42, 95% CI 2.15-2.71) and anemia (OR 1.75, 95% CI 1.65-1.87) predicted poor adherence to guidelines. In those with cancer, anemia (OR 1.83, 95% CI 1.64-2.06), immobility (OR 1.51, 95% CI 1.30-1.76) and metastases (OR 3.22, 95% CI 2.87-3.61) predicted long-term LMWH therapy. In conclusion, we report practices of VTE therapy in real life and found that a significant proportion of patients did not receive the recommended treatment. The perceived increased risk for bleeding has an impact on anticoagulant treatment decision. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0128741 | - |
dc.relation.ispartof | PLoS Medicine, 2015, vol. 10, num. 6, p. e0128741 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0128741 | - |
dc.rights | cc-by (c) Mahé, Isabelle et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Tromboembolisme | - |
dc.subject.classification | Anticoagulants (Medicina) | - |
dc.subject.classification | Càncer de ronyó | - |
dc.subject.other | Thromboembolism | - |
dc.subject.other | Anticoagulants (Medicine) | - |
dc.subject.other | Renal cancer | - |
dc.title | Long-Term Anticoagulant Therapy of Patients with Venous Thromboembolism. What Are the Practices? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 681937 | - |
dc.date.updated | 2021-03-16T11:46:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26076483 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) |
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681937.pdf | 950.82 kB | Adobe PDF | View/Open |
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