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Title: The 'unnatural' history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance
Author: Ahadova, Aysel
Seppälä, Toni T.
Engel, Christoph
Gallon, Richard
Burn, John
Holinski Feder, Elke
Steinke Lange, Verena
Möslein, Gabriela
Nielsen, Maartje
Ten Broeke, Sanne W.
Laghi, Luigi
Dominguez Valentin, Mev
Capellá, G. (Gabriel)
Macrae, Finlay
Scott, Rodney
Hüneburg, Robert
Nattermann, Jacob
Hoffmeister, Michael
Brenner, Hermann
Bläker, Hendrik
von Knebel Doeberitz, Magnus
Sampson, Julian R.
Vasen, Hans
Mecklin, Jukka Pekka
Møller, Pål
Kloor, Matthias
Keywords: Càncer colorectal
Colorectal cancer
Issue Date: 15-Feb-2021
Publisher: Wiley
Abstract: Individuals with Lynch syndrome (LS), one of the most common inherited cancer syndromes, are at increased risk of developing malignancies, in particular colorectal cancer (CRC). Regular colonoscopy with polypectomy is recommended to reduce CRC risk in LS individuals. However, recent independent studies demonstrated that a substantial proportion of LS individuals develop CRC despite regular colonoscopy. The reasons for this surprising observation confirmed by large prospective studies are a matter of debate. In this review, we collect existing evidence from clinical, epidemiological and molecular studies and interpret them with regard to the origins and progression of LS-associated CRC. Alongside with hypotheses addressing colonoscopy quality and pace of progression from adenoma to cancer, we discuss the role of alternative precursors and immune system in LS-associated CRC. We also identify gaps in current knowledge and make suggestions for future studies aiming at improved CRC prevention for LS individuals.
Note: Reproducció del document publicat a:
It is part of: International Journal of Cancer, 2021, vol. 148(4), p. 800-811
Related resource:
ISSN: 0020-7136
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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