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http://hdl.handle.net/2445/175264
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DC Field | Value | Language |
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dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Schettini, Francesco | - |
dc.contributor.author | Chic Ruché, Núria | - |
dc.contributor.author | Brasó Maristany, Fara | - |
dc.contributor.author | Paré, Laia | - |
dc.contributor.author | Pascual, Tomás | - |
dc.contributor.author | Conte, Benedetta | - |
dc.contributor.author | Martínez Sáez, Olga | - |
dc.contributor.author | Adamo, Barbara | - |
dc.contributor.author | Vidal Losada, Maria Jesús | - |
dc.contributor.author | Fernández Martínez, Aranzazu | - |
dc.contributor.author | González Farré, Blanca | - |
dc.contributor.author | Sanfeliu, Esther | - |
dc.contributor.author | Cejalvo Andújar, Juan Miguel | - |
dc.contributor.author | Perrone, Giuseppe | - |
dc.contributor.author | Sabarese, Giovanna | - |
dc.contributor.author | Zalfa, Francesca | - |
dc.contributor.author | Villagrasa, Patricia | - |
dc.contributor.author | Gavilá, Joaquín | - |
dc.contributor.author | Barrios, Carlos H. | - |
dc.contributor.author | Lluch, Ana | - |
dc.contributor.author | Martín, Miguel | - |
dc.contributor.author | Placido, Sabino De | - |
dc.contributor.author | Barnadas, Esther | - |
dc.contributor.author | Locci, Mariavittoria | - |
dc.contributor.author | Peg, Vicente | - |
dc.contributor.author | Fasan, Roberta | - |
dc.date.accessioned | 2021-03-17T15:54:35Z | - |
dc.date.available | 2021-03-17T15:54:35Z | - |
dc.date.issued | 2021-01-04 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175264 | - |
dc.description.abstract | Novel antibody-drug conjugates against HER2 are showing high activity in HER2-negative breast cancer (BC) with low HER2 expression (i.e., 1+ or 2+ and lack of ERBB2 amplification). However, the clinical and molecular features of HER2-low BC are yet to be elucidated. Here, we collected retrospective clinicopathological and PAM50 data from 3,689 patients with HER2-negative disease and made the following observations. First, the proportion of HER2-low was higher in HR-positive disease (65.4%) than triple-negative BC (TNBC, 36.6%). Second, within HR-positive disease, ERBB2 and luminal-related genes were more expressed in HER2-low than HER2 0. In contrast, no gene was found differentially expressed in TNBC according to HER2 expression. Third, within HER2-low, ERBB2 levels were higher in HR-positive disease than TNBC. Fourth, HER2-low was not associated with overall survival in HR-positive disease and TNBC. Finally, the reproducibility of HER2-low among pathologists was suboptimal. This study emphasizes the large biological heterogeneity of HER2-low BC, and the need to implement reproducible and sensitive assays to measure low HER2 expression. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Nature | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41523-020-00208-2 | - |
dc.relation.ispartof | Npj Breast Cancer, 2021, vol. 7 | - |
dc.relation.uri | https://doi.org/10.1038/s41523-020-00208-2 | - |
dc.rights | cc-by (c) Prat, Aleix et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Gene expression | - |
dc.title | Clinical, pathological and PAM50 gene expression features of HER2-low breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 706374 | - |
dc.date.updated | 2021-03-17T15:54:36Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/847912/EU//RESCUER | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33397968 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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706374.pdf | 1.69 MB | Adobe PDF | View/Open |
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