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Title: Sex differences in oncogenic mutational processes
Author: Li, Constance H.
Prokopec, Stephenie D.
Sun, Ren X.
Yousif, Fouad
Schmitz, Nathaniel
PCAWG Tumour Subtypes
Clinical Translation, Boutros, P.C.
PCAWG Consortium
Rabionet Janssen, Raquel
López Guillermo, Armando
Aymerich Gregorio, Marta
Campo Güerri, Elias
Gelpí Buchaca, Josep Lluís
Martín-Subero, José Ignacio
Keywords: Càncer
Estudis de gènere
Gender studies
Issue Date: 1-Sep-2020
Publisher: Nature Publishing Group
Abstract: Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.
Note: Reproducció del document publicat a:
It is part of: Nature Communications, 2020, vol. 11, p. 4330
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ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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