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http://hdl.handle.net/2445/175301
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DC Field | Value | Language |
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dc.contributor.author | van Duijnhoven, Franzel J. B. | - |
dc.contributor.author | Jenab, Mazda | - |
dc.contributor.author | Hveem, Kristian | - |
dc.contributor.author | Siersema, Peter D. | - |
dc.contributor.author | Fedirko, Veronika | - |
dc.contributor.author | Duell, Eric J. | - |
dc.contributor.author | Kampman, Ellen | - |
dc.contributor.author | Halfweeg, Anouk | - |
dc.contributor.author | van Kranen, Henk J. | - |
dc.contributor.author | van den Ouweland, Jody M. W. | - |
dc.contributor.author | Weiderpass, Elisabete | - |
dc.contributor.author | Murphy, Neil | - |
dc.contributor.author | Langhammer, Arnulf | - |
dc.contributor.author | Ness-Jensen, Eivind | - |
dc.contributor.author | Olsen, Anja | - |
dc.contributor.author | Tjønneland, Anne | - |
dc.contributor.author | Overvad, Kim | - |
dc.contributor.author | Cadeau, Claire | - |
dc.contributor.author | Kvaskoff, Marina | - |
dc.contributor.author | Boutron-Ruault, Marie-Christine | - |
dc.contributor.author | Katzke, Verena | - |
dc.contributor.author | Kühn, Tilman | - |
dc.contributor.author | Boeing, Heiner | - |
dc.contributor.author | Trichopoulou, Antonia | - |
dc.contributor.author | Kotanidou, Anastasia | - |
dc.contributor.author | Kritikou, Maria | - |
dc.contributor.author | Palli, Domenico | - |
dc.contributor.author | Agnoli, Claudia | - |
dc.contributor.author | Tumino, Rosario | - |
dc.contributor.author | Panico, Salvatore | - |
dc.contributor.author | Matullo, Giuseppe | - |
dc.contributor.author | Peeters, Petra H. M. | - |
dc.contributor.author | Brustad, Magritt | - |
dc.contributor.author | Olsen, Karina Standahl | - |
dc.contributor.author | Lasheras, Cristina | - |
dc.contributor.author | Obón Santacana, Mireia | - |
dc.contributor.author | Sánchez, María José | - |
dc.contributor.author | Dorronsoro, Miren | - |
dc.contributor.author | Chirlaque, María Dolores | - |
dc.contributor.author | Barricarte, Aurelio | - |
dc.contributor.author | Manjer, Jonas | - |
dc.contributor.author | Almquist, Martin | - |
dc.contributor.author | Renström, Frida | - |
dc.contributor.author | Ye, Weimin | - |
dc.contributor.author | Wareham, Nick | - |
dc.contributor.author | Khaw, Kay-Tee | - |
dc.contributor.author | Bradbury, Kathryn E. | - |
dc.contributor.author | Freisling, Heinz | - |
dc.contributor.author | Aune, Dagfinn | - |
dc.contributor.author | Norat, Teresa | - |
dc.contributor.author | Riboli, Elio | - |
dc.contributor.author | Bueno de Mesquita, H. Bas | - |
dc.date.accessioned | 2021-03-18T11:25:13Z | - |
dc.date.available | 2021-03-18T11:25:13Z | - |
dc.date.issued | 2017-11-22 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175301 | - |
dc.description.abstract | Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/ijc.31146 | - |
dc.relation.ispartof | International Journal of Cancer, 2017, vol. 142, num. 6, p. 1189-1201 | - |
dc.relation.uri | https://doi.org/10.1002/ijc.31146 | - |
dc.rights | cc by-nc-nd (c) van Duijnhoven et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de pàncrees | - |
dc.subject.classification | Vitamina D | - |
dc.subject.other | Pancreas cancer | - |
dc.subject.other | Vitamin D | - |
dc.title | Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-03-17T10:17:53Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/232997/EU//TICE | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29114875 | - |
Appears in Collections: | Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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ijc.31146.pdf | 530.45 kB | Adobe PDF | View/Open |
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