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Title: Plasma exchange: An efective rescue therapy in critically ill patients with coronavirus disease 2019 infection
Author: Fernández Gómez, Javier
Gratacos, Jordi
Olivas, Pol
Costa, Montserrat
Nieto, Susana
Mateo Ortega, Dolors
Sánchez, M.Belén
Aguilar, Ferran
Bassegoda, Octavio
Ruiz, Pablo
Caballol, Berta
Pocurull, Anna
Llach, Joan
Mustieles, M.Jesús
Cid, Joan
Reverter, Enric
Toapanta, Nestor David
Hernández-Tejero, María
Martínez, José Antonio
Clària i Enrich, Joan
Fernández, Carlos
Mensa Pueyo, Josep
Arroyo, Vicente
Castro, Pedro
Lozano Molero, Miguel
Keywords: COVID-19
Plasma sanguini
Blood plasma
Issue Date: 1-Dec-2020
Publisher: Lippincott, Williams & Wilkins
Abstract: Objectives: Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can be used as rescue therapy in these patients. Design: Single center case series. Setting: Local study. Subjects: Four critically ill adults with coronavirus disease 19 pneumonia that failed conventional interventions. Interventions: Plasma exchange. Two to six sessions (1.2 plasma volumes). Human albumin (5%) was used as the main replacement fluid. Fresh frozen plasma and immunoglobulins were administered after each session to avoid coagulopathy and hypogammaglobulinemia. Measurements and main results: Serum markers of inflammation and macrophage activation. All patients showed a dramatic reduction in inflammatory markers, including the main cytokines, and improved severity scores after plasma exchange. All survived to ICU admission. Conclusions: Plasma exchange mitigates cytokine storm, reverses organ failure, and could improve survival in critically ill patients with coronavirus disease 2019 infection.
Note: Reproducció del document publicat a:
It is part of: Critical Care Medicine, 2020, vol. 48, num. 12, p. e1350-e1355
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ISSN: 0090-3493
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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