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Title: | Plasma exchange: An efective rescue therapy in critically ill patients with coronavirus disease 2019 infection |
Author: | Fernández Gómez, Javier Gratacós Ginès, Jordi Olivas, Pol Costa, Montserrat Nieto, Susana Mateo Ortega, Dolors Sánchez, M.Belén Aguilar, Ferran Bassegoda, Octavi Ruiz, Pablo Caballol, Berta Pocurull, Anna Llach, Joan Mustieles, M.Jesús Cid Vidal, Joan Reverter, Enric Toapanta, David Hernández-Tejero, María Martínez, José Antonio Clària i Enrich, Joan Fernández, Carlos Mensa Pueyo, Josep Arroyo, Vicente Castro, Pedro Lozano Molero, Miguel |
Keywords: | COVID-19 Plasma sanguini COVID-19 Blood plasma |
Issue Date: | 1-Dec-2020 |
Publisher: | Lippincott, Williams & Wilkins |
Abstract: | Objectives: Infection by severe acute respiratory syndrome coronavirus-2 can induce uncontrolled systemic inflammation and multiple organ failure. The aim of this study was to evaluate if plasma exchange, through the removal of circulating mediators, can be used as rescue therapy in these patients. Design: Single center case series. Setting: Local study. Subjects: Four critically ill adults with coronavirus disease 19 pneumonia that failed conventional interventions. Interventions: Plasma exchange. Two to six sessions (1.2 plasma volumes). Human albumin (5%) was used as the main replacement fluid. Fresh frozen plasma and immunoglobulins were administered after each session to avoid coagulopathy and hypogammaglobulinemia. Measurements and main results: Serum markers of inflammation and macrophage activation. All patients showed a dramatic reduction in inflammatory markers, including the main cytokines, and improved severity scores after plasma exchange. All survived to ICU admission. Conclusions: Plasma exchange mitigates cytokine storm, reverses organ failure, and could improve survival in critically ill patients with coronavirus disease 2019 infection. |
Note: | Reproducció del document publicat a: https://doi.org/10.1097/CCM.0000000000004613 |
It is part of: | Critical Care Medicine, 2020, vol. 48, num. 12, p. e1350-e1355 |
URI: | http://hdl.handle.net/2445/175340 |
Related resource: | https://doi.org/10.1097/CCM.0000000000004613 |
ISSN: | 0090-3493 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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