Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/175417
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tort-Merino, Adrià | - |
dc.contributor.author | Olives, Jaume | - |
dc.contributor.author | León, María | - |
dc.contributor.author | Peñaloza, Claudia | - |
dc.contributor.author | Valech, Natalia | - |
dc.contributor.author | Santos-Santos, Miguel A. | - |
dc.contributor.author | Camara Mancha, Estela | - |
dc.contributor.author | Grönholm-Nyman, Petra | - |
dc.contributor.author | Martínez-Lage Álvarez, Pablo | - |
dc.contributor.author | Fortea, Juan | - |
dc.contributor.author | Molinuevo, José Luis | - |
dc.contributor.author | Sánchez del Valle Díaz, Raquel | - |
dc.contributor.author | Laine, Matti | - |
dc.contributor.author | Rodríguez Fornells, Antoni | - |
dc.contributor.author | Rami, Lorena | - |
dc.date.accessioned | 2021-03-19T10:59:33Z | - |
dc.date.available | 2021-03-19T10:59:33Z | - |
dc.date.issued | 2019-07-02 | - |
dc.identifier.issn | 1387-2877 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175417 | - |
dc.description.abstract | Background: We investigated a sample of cognitively healthy subjects with normal Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarker levels to identify the earliest variables related to longitudinal memory changes. Objective: Employing a new highly demanding learning and memory test (the Ancient Farming Equipment Test; AFE-T), we aimed to investigate whether a biomarker related to neurodegeneration (i.e., CSF tau) was associated with longitudinal memory decline. Methods: Thirty-two cognitively and biologically normal (CBN) subjects underwent MRI, neuropsychological assessment, and the AFE-T at baseline and 18 months later. To explore the relationship between cognitive performance and relevant factors, a linear model was set up. For a secondary analysis that further explore the effect of tau, the subjects were divided into CBN-Tau↓ (tau < 228.64 pg/ml; n = 16) and CBN-Tau↑ (tau > 228.64 pg/ml; n = 16). We also performed voxel-based morphometry (VBM) to identify regions of grey matter volume that would predict both baseline and longitudinal cognitive performance. Results: Our main finding was an association between CSF tau and longitudinal memory decline measured with AFE-T (B = -0.17, p < 0.05; r = -0.414; p < 0.01), and further analyses showed different evolvement between subgroups, with an accelerated decline in individuals with higher tau (F(1,31) = 8.37; p < 0.01). VBM results suggested that AFE-T performance is related to grey matter volume in a medial temporal, middle frontal, and posterior cerebellar network at baseline, and that there are strategic brain areas driving the longitudinal cognitive changes. Conclusions: The present findings provide evidence for structural and biological markers linked to cognitive aging by highlighting the role of tau, a marker of neurodegeneration, which can be related with the earliest memory changes in healthy subjects. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | IOS Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3233/JAD-190046 | - |
dc.relation.ispartof | Journal of Alzheimer's Disease, 2019, vol. 70, num. 1, p. 211-225 | - |
dc.relation.uri | https://doi.org/10.3233/JAD-190046 | - |
dc.rights | (c) Tort-Merino, Adrià et al., 2019 | - |
dc.source | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) | - |
dc.subject.classification | Malaltia d'Alzheimer | - |
dc.subject.classification | Trastorns de la memòria | - |
dc.subject.classification | Envelliment cerebral | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.other | Alzheimer's disease | - |
dc.subject.other | Memory disorders | - |
dc.subject.other | Aging brain | - |
dc.subject.other | Biochemical markers | - |
dc.title | Tau Protein is Associated with Longitudinal Memory Decline in Cognitively Healthy Subjects with Normal Alzheimer's Disease Cerebrospinal Fluid Biomarker Levels | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 705008 | - |
dc.date.updated | 2021-03-19T10:59:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
705008.pdf | 1.49 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.