Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/175514
Title: A Prospective Evaluation of Plasma Polyphenol Levels and Colon Cancer Risk
Author: Murphy, Neil
Achaintre, David
Zamora-Ros, Raul
Jenab, Mazda
Boutron-Ruault, Marie-Christine
Carbonnel, Franck
Savoye, Isabelle
Kaaks, Rudolf
Kühn, Tilman
Boeing, Heiner
Aleksandrova, Krasimira
Tjønneland, Anne
Kyrø, Cecilie
Overvad, Kim
Quirós, J. Ramón
Sánchez, Maria Jose
Altzibar, Jone M.
Huerta, José María
Barricarte, Aurelio
Khaw, Kay‐Tee
Bradbury, Kathryn E.
Pérez Cornago, Aurora
Trichopoulou, Antonia
Karakatsani, Anna
Peppa, Eleni
Palli, Domenico
Grioni, Sara
Tumino, Rosario
Sacerdote, Carlotta
Panico, Salvatore
Bueno de Mesquita, H. Bas
Peeters, Petra H.
Rutegård, Martin
Johansson, Ingegerd
Freisling, Heinz
Noh, Hwayoung
Cross, Amanda J.
Vineis, Paolo
Tsilidis, Kostas
Gunter, Marc J.
Scalbert, Augustin
Keywords: Marcadors bioquímics
Càncer colorectal
Estudi de casos
Polifenols
Biochemical markers
Colorectal cancer
Case studies
Polyphenols
Issue Date: 11-Jun-2018
Publisher: Wiley
Abstract: Polyphenols have been shown to exert biological activity in experimental models of colon cancer; however, human data linking specific polyphenols to colon cancer is limited. We assessed the relationship between pre-diagnostic plasma polyphenols and colon cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition study. Using high pressure liquid chromatography coupled to tandem mass spectrometry, we measured concentrations of 35 polyphenols in plasma from 809 incident colon cancer cases and 809 matched controls. We used multivariable adjusted conditional logistic regression models that included established colon cancer risk factors. The false discovery rate (qvalues ) was computed to control for multiple comparisons. All statistical tests were two-sided. After false discovery rate correction and in continuous log2 -transformed multivariable models, equol (odds ratio [OR] per log2 -value, 0.86, 95% confidence interval [95% CI] = 0.79-0.93; qvalue = 0.01) and homovanillic acid (OR per log2 -value, 1.46, 95% CI = 1.16-1.84; qvalue = 0.02) were associated with colon cancer risk. Comparing extreme fifths, equol concentrations were inversely associated with colon cancer risk (OR = 0.61, 95% CI = 0.41-0.91, ptrend = 0.003), while homovanillic acid concentrations were positively associated with colon cancer development (OR = 1.72, 95% CI = 1.17-2.53, ptrend < 0.0001). No heterogeneity for these associations was observed by sex and across other colon cancer risk factors. The remaining polyphenols were not associated with colon cancer risk. Higher equol concentrations were associated with lower risk, and higher homovanillic acid concentrations were associated with greater risk of colon cancer. These findings support a potential role for specific polyphenols in colon tumorigenesis.
Note: Reproducció del document publicat a: https://doi.org/10.1002/ijc.31563
It is part of: International Journal of Cancer, 2018, vol. 143, issue. 7, p. 1620-1631
URI: http://hdl.handle.net/2445/175514
Related resource: https://doi.org/10.1002/ijc.31563
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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