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Title: | Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients |
Author: | Quintairos Domenech, Luis Colom Codina, Helena Millán, Olga Fortuna, Virginia Espinosa, Cristina Guirado, Lluís Budde, Klemens Sommerer, Claudia Lizana, Ana López Púa, Yolanda Brunet i Serra, Mercè |
Keywords: | Marcadors bioquímics Farmacocinètica Trasplantament renal Factors de risc en les malalties Biochemical markers Pharmacokinetics Kidney transplantation Risk factors in diseases |
Issue Date: | 22-Jan-2021 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0245880 |
It is part of: | PLoS One, 2021, vol. 16, num. 1, p. e0245880 |
URI: | http://hdl.handle.net/2445/175587 |
Related resource: | https://doi.org/10.1371/journal.pone.0245880 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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