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Title: Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction
Author: Youssef, Lina
Erlandsson, Lena
Åkerström, Bo
Miranda, Jezid
Paules, Cristina
Crovetto, Francesca
Crispi Brillas, Fàtima
Gratacós Solsona, Eduard
Hansson, Stefan R.
Keywords: Hipertensió en l'embaràs
Estrès oxidatiu
Malalties de la placenta
Hypertension in pregnancy
Oxidative stress
Placenta Diseases
Issue Date: 11-Sep-2020
Publisher: Public Library of Science (PLoS)
Abstract: Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated maternal and fetal plasma concentrations of these scavengers in the different phenotypes of placenta-mediated disorders. Singleton pregnancies with normotensive fetal growth restriction [FGR] (n = 47), preeclampsia without FGR (n = 45) and preeclampsia with FGR (n = 51) were included prospectively as well as uncomplicated pregnancies (n = 49). Samples were collected at delivery and ELISA analysis was applied to measure the hemopexin and α1-microglobulin concentrations. In maternal blood in preeclampsia with and without FGR, hemopexin was significantly lower (p = 0.003 and p<0.001, respectively) and α1-microglobulin was significantly higher (p<0.001 in both) whereas no difference existed in normotensive FGR mothers compared to controls. In contrast, in fetal blood in growth restricted fetuses with and without preeclampsia, both hemopexin and α1-microglobulin were significantly lower (p<0.001 and p = 0.001 for hemopexin, p = 0.016 and p = 0.013 for α1-microglobulin, respectively) with no difference in fetuses from preeclampsia without FGR in comparison to controls. Thus, hemopexin and α1-microglobulin present significantly altered concentrations in maternal blood in the maternal disease -preeclampsia- and in cord blood in the fetal disease -FGR-, which supports their differential role in placenta-mediated disorders in accordance with the clinical presentation of these disorders.
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It is part of: PLoS One, 2020, vol. 15, num. 9, p. e0239030
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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