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DC Field | Value | Language |
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dc.contributor.author | Schepers, Elaine | - |
dc.contributor.author | Lousberg, Richel | - |
dc.contributor.author | Guloksuz, Sinan | - |
dc.contributor.author | Pries, Lotta-Katrin | - |
dc.contributor.author | Delespaul, Philippe | - |
dc.contributor.author | Kenis, Gunter | - |
dc.contributor.author | Luykx, Jurjen J. | - |
dc.contributor.author | Lin, Bochao D. | - |
dc.contributor.author | Richards, Alexander L. | - |
dc.contributor.author | Akdede, Berna | - |
dc.contributor.author | Binbay, Tolga | - |
dc.contributor.author | Altınyazar, Vesile | - |
dc.contributor.author | Yalınçetin, Berna | - |
dc.contributor.author | Gümüş-Akay, Güvem | - |
dc.contributor.author | Cihan, Burçin | - |
dc.contributor.author | Soygür, Haldun | - |
dc.contributor.author | Ulas, Halis | - |
dc.contributor.author | Cankurtaran, Eylem Sahin | - |
dc.contributor.author | Bernardo Arroyo, Miquel | - |
dc.contributor.author | Cabrera Llorca, Bibiana | - |
dc.contributor.author | Kaymak, Semra Ulusoy | - |
dc.contributor.author | Mihaljevic, Marina M. | - |
dc.contributor.author | Petrovic, Sanja Andric | - |
dc.contributor.author | Mirjanic, Tijana | - |
dc.contributor.author | Bernardo Arroyo, Miquel | - |
dc.contributor.author | Bobes García, Julio | - |
dc.contributor.author | Saiz, Pilar A. | - |
dc.contributor.author | García-Portilla González, María Paz, 1962- | - |
dc.contributor.author | Sanjuan, Julio | - |
dc.contributor.author | Aguilar, Eduardo | - |
dc.contributor.author | Jiménez López, Estela | - |
dc.contributor.author | Arrojo, Manuel | - |
dc.contributor.author | Carracedo Álvarez, Ángel | - |
dc.contributor.author | López, Gonzalo | - |
dc.contributor.author | González Peñas, Javier | - |
dc.contributor.author | Parellada, Mara | - |
dc.contributor.author | Maric, Nadja P. | - |
dc.contributor.author | Atbaşoğlu, Cem | - |
dc.contributor.author | Ucok, Alp | - |
dc.contributor.author | Alptekin, Köksal | - |
dc.contributor.author | Can Saka, Meram | - |
dc.contributor.author | Arango, Celso | - |
dc.contributor.author | Rutten, Bart P.F. | - |
dc.contributor.author | van Os, Jim | - |
dc.date.accessioned | 2021-03-24T14:58:07Z | - |
dc.date.available | 2021-03-24T14:58:07Z | - |
dc.date.issued | 2019-09-25 | - |
dc.identifier.issn | 1664-0640 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175685 | - |
dc.description.abstract | Introduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability]. Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores. Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow CAPE positive scale 0.96, 95% CI 0.85-1.07; ORhigh CAPE positive scale 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p interaction < 0.001; ORhigh cognitive ability 0.94, 95% CI 0.84-1.05; ORlow cognitive ability 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction < 0.001; ORlow adversity 0.92, 95% CI 0.82-1.04; ORhigh adversity 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232). Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fpsyt.2019.00676 | - |
dc.relation.ispartof | Frontiers In Psychiatry, 2019, vol. 10 | - |
dc.relation.uri | https://doi.org/10.3389/fpsyt.2019.00676 | - |
dc.rights | cc-by (c) Schepers, Elaine et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Psicosi | - |
dc.subject.classification | Infància | - |
dc.subject.other | Psychoses | - |
dc.subject.other | Childhood | - |
dc.title | White noise speech illusions: a trait-dependent risk marker for psychotic disorder? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695310 | - |
dc.date.updated | 2021-03-24T14:58:07Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/241909/EU//EU-GEI | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31607966 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Publicacions de projectes de recerca finançats per la UE |
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