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Title: A bibliographic review on capuramycin, a nucleosidic natural product with antibiotic properties
Other Titles: Una revisió bibliogràfica sobre la capuramicina, un nucleòsid natural amb propietats antibiòtiques
Author: Ruiz Font, Elisabet
Director/Tutor: Robles i Brau, Jordi
Keywords: Antibiòtics
Síntesi orgànica
Treballs de fi de grau
Organic synthesis
Bachelor's theses
Issue Date: Jul-2020
Abstract: Antibacterial resistance has become an urgent issue for human being and animal’s health. Among these resistant bacteria stand out important pathogens such as M. tuberculosis, M. smegmatis and S. pneumoniae. Notably, these pathogens were inhibited by natural uridine antibiotics such as capuramycin, a compound first isolated from Streptomyces griseus. This type of antibiotics acts by inhibiting MraY, an enzyme involved in the biosynthesis of peptydoglican component of the bacteria cell wall, but showed low antibacterial activity. Consequently, capuramycin analogues have been prepared by organic synthesis and biosynthesis to allow structure-activity studies as a prior step towards the development of new antibacterial drugs. In this context, this present TFG report contains a bibliographic review on capuramycin, with a particular emphasis on the synthetic routes of the compound and its derivatives, the elucidation of the biosynthetic pathways and their applications, and studies of structure-antibacterial activity.
Note: Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2020, Tutor: Jordi Robles Brau
Appears in Collections:Treballs Finals de Grau (TFG) - Química

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