Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/175883
Title: Hippocampus and insula are targets in epileptic patients with glutamic acid decarboxylase antibodies
Author: Falip, Mercè
Rodríguez Bel, Laura
Castañer, Sara
Sala Padró, Jacint
Miró, Júlia
Jaraba, Sónia
Casasnovas Pons, Carlos
Morandeira-Rego, Francisco
Berdejo, Javier
Carreño, Mar
Keywords: Epilèpsia
Hipocamp (Cervell)
Sistema límbic
Epilepsy
Hippocampus (Brain)
Limbic system
Issue Date: 9-Jan-2019
Publisher: Frontiers Media
Abstract: Background: Antibodies to glutamic acid decarboxylase (GAD ab) have been found in patients with limbic encephalitis (LE) and chronic pharmacoresistant focal epilepsy (FE). The objectives of the study were to: (1) analyze the clinical and neuroimaging course of patients with FE+GAD ab, (2) compare these characteristics with a control group, and (3) describe the most affected cerebral areas with structural and functional imaging. Methods: Patients with FE + high titers of GAD ab and a follow-up of at least 5 years were selected. Titers of serum GAD ab exceeding 2,000 UI/ml were considered high. Evolutive clinical and radiological characteristics were studied in comparison to two different control groups: patients with bilateral or with unilateral mesial temporal sclerosis (BMTS or UMTS) of a non-autoimmune origin. Results: A group of 13 patients and 17 controls were included (8 BMTS, 9 UMTS). The most frequent focal aware seizures (FAS) reported by patients were psychic (5/13: 33%). Somatosensorial, motor, and visual FAS (4/13:32%) (p: 0.045), musicogenic reflex seizures (MRS), and a previous history of cardiac syncope were reported only patients (2/13:16% each) (p: NS). Comparing EEG characteristics between patients and controls, a more widespread distribution of interictal epileptiform discharges (IED) was observed in FE+ GAD ab patients than in controls (p:0.01). Rhythmic delta activity was observed in all controls in anterior temporal lobes while in patients this was less frequent (p: 0.001). No IED, even in 24 h cVEEG, was seen in 6 patients (46%).First MRI was normal in 4/5 (75%) patients. During the follow-up mesial temporal lobe (MTsL) sclerosis was observed in 5/8 (62%) of patients. All patients had abnormal FDG-PET study. MTL hypometabolism was observed in 10/11 (91%) patients, being bilateral in 7/11 (63%). In controls, this was observed in 16/17 (94%), and it was bilateral in 8/17 (47%) (p: NS). Insular hypometabolism was observed in 5/11 (45%) patients (P:0.002). Conclusions: Clinical, EEG, and FDG-PET findings in FE+GAD ab suggest a widespread disease not restricted to the temporal lobe. Progressive MTL sclerosis may be observed during follow-up. In comparison to what is found in patients with non-autoimmune MTL epilepsy, insular hypometabolism is observed only in patients with GAD ab, so it may be an important diagnostic clue.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fneur.2018.01143
It is part of: Frontiers In Neurology, 2019, vol. 9
URI: http://hdl.handle.net/2445/175883
Related resource: https://doi.org/10.3389/fneur.2018.01143
ISSN: 1664-2295
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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