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Title: | Lower Locus Coeruleus MRI intensity in patients with late-life major depression |
Author: | Guinea Izquierdo, Andrés Giménez, Mònica Martínez Zalacaín, Ignacio Cerro San Ildefonso, Inés del Canal Noguer, Pol Blasco, Gerard Gascón-Bayarri, Jordi Reñé Ramírez, Ramon Rico, Inmaculada Camins, Àngels Aguilera, Carles Urretavizcaya Sarachaga, Mikel Ferrer, Isidro (Ferrer Abizanda) Menchón Magriñá, José Manuel Soria, Virginia Soriano Mas, Carles |
Keywords: | Neurociència cognitiva Malalties del sistema nerviós central Cognitive neuroscience Central nervous system diseases |
Issue Date: | 16-Feb-2021 |
Publisher: | PeerJ |
Abstract: | Background: The locus coeruleus (LC) is the major noradrenergic source in the central nervous system. Structural alterations in the LC contribute to the pathophysiology of different neuropsychiatric disorders, which may increase to a variable extent the likelihood of developing neurodegenerative conditions. The characterization of such alterations may therefore help to predict progression to neurodegenerative disorders. Despite the LC cannot be visualized with conventional magnetic resonance imaging (MRI), specific MRI sequences have been developed to infer its structural integrity. Methods: We quantified LC signal Contrast Ratios (LCCRs) in late-life major depressive disorder (MDD) (n = 37, 9 with comorbid aMCI), amnestic Mild Cognitive Impairment (aMCI) (n = 21, without comorbid MDD), and healthy controls (HCs) (n = 31), and also assessed the putative modulatory effects of comorbidities and other clinical variables. Results: LCCRs were lower in MDD compared to aMCI and HCs. While no effects of aMCI comorbidity were observed, lower LCCRs were specifically observed in patients taking serotonin/norepinephrine reuptake inhibitors (SNRIs). Conclusion: Our results do not support the hypothesis that lower LCCRs characterize the different clinical groups that may eventually develop a neurodegenerative disorder. Conversely, our results were specifically observed in patients with late-life MDD taking SNRIs. Further research with larger samples is warranted to ascertain whether medication or particular clinical features of patients taking SNRIs are associated with changes in LC neurons. |
Note: | Reproducció del document publicat a: https://doi.org/10.7717/peerj.10828 |
It is part of: | PeerJ, 2021, vol. 9 |
URI: | http://hdl.handle.net/2445/176018 |
Related resource: | https://doi.org/10.7717/peerj.10828 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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