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Title: A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease
Author: Boyer Díaz, Zoe
Domingo i Pedrol, Joan Carles
De Gregorio, Estefanía
Manicardi, Nicolò
Aristu Zabalza, Peio
Cordobilla, Begoña
Abad Jordà, Laia
Ortega Ribera, Martí
Fernández Iglesias, Anabel
Marí, Montserrat
Bosch, Jaime
Gracia Sancho, Jordi
Keywords: Malalties del fetge
Hipertensió portal
Cirrosi hepàtica
Liver diseases
Portal hypertension
Hepatic cirrhosis
Issue Date: 3-Oct-2019
Publisher: MDPI
Abstract: Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA) as a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation (500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell (HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine macrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA reestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH. The mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress and inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments with cultured macrophages showed that treatment with DHA protects against pro-inflammatory insults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly improves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven HSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2019, vol. 11, num. 10, p. 2358
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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