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Title: | A Nutraceutical Rich in Docosahexaenoic Acid Improves Portal Hypertension in a Preclinical Model of Advanced Chronic Liver Disease |
Author: | Boyer Díaz, Zoe Domingo i Pedrol, Joan Carles De Gregorio, Estefanía Manicardi, Nicolò Aristu Zabalza, Peio Cordobilla, Begoña Abad Jordà, Laia Ortega Ribera, Martí Fernández Iglesias, Anabel Marí, Montserrat Bosch, Jaime Gracia Sancho, Jordi |
Keywords: | Malalties del fetge Hipertensió portal Cirrosi hepàtica Liver diseases Portal hypertension Hepatic cirrhosis |
Issue Date: | 3-Oct-2019 |
Publisher: | MDPI |
Abstract: | Inflammation and oxidative stress play a key role in the pathophysiology of advanced chronic liver disease (ACLD) and portal hypertension (PH). Considering the current lack of effective treatments, we evaluated an anti-inflammatory and antioxidant nutraceutical rich in docosahexaenoic acid (DHA) as a possible therapy for ACLD. We investigated the effects of two-week DHA supplementation (500 mg/kg) on hepatic fatty acids, PH, oxidative stress, inflammation, and hepatic stellate cell (HSC) phenotype in rats with ACLD. Additionally, the effects of DHA were evaluated in murine macrophages and human HSC. In contrast to vehicle-treated animals, cirrhotic rats receiving DHA reestablished a healthy hepatic fatty acid profile, which was associated with an improvement in PH. The mechanisms underlying this hemodynamic improvement included a reduction in oxidative stress and inflammation, as well as a marked HSC deactivation, confirmed in human HSC. Experiments with cultured macrophages showed that treatment with DHA protects against pro-inflammatory insults. The present preclinical study demonstrates that a nutraceutical rich in DHA significantly improves PH in chronic liver disease mainly by suppressing inflammation and oxidative stress-driven HSC activation, encouraging its evaluation as a new treatment for PH and cirrhosis. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/nu12030719 |
It is part of: | Nutrients, 2019, vol. 11, num. 10, p. 2358 |
URI: | http://hdl.handle.net/2445/176048 |
Related resource: | https://doi.org/10.3390/nu12030719 |
ISSN: | 2072-6643 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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