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DC Field | Value | Language |
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dc.contributor.author | Fernández Bañares, Fernando | - |
dc.contributor.author | Carrasco García, Anna | - |
dc.contributor.author | Rosinach, Mercè | - |
dc.contributor.author | Arau, Beatriz | - |
dc.contributor.author | García Puig, Roger | - |
dc.contributor.author | González, Clarisa | - |
dc.contributor.author | Tristán, Eva | - |
dc.contributor.author | Zabana, Yamile | - |
dc.contributor.author | Esteve i Comas, Maria | - |
dc.date.accessioned | 2021-04-08T10:10:53Z | - |
dc.date.available | 2021-04-08T10:10:53Z | - |
dc.date.issued | 2019-05-10 | - |
dc.identifier.issn | 2072-6643 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176060 | - |
dc.description.abstract | Background & aims: Determining whether patients with lymphocytic enteritis (LE) have coeliac disease is a challenge. We analysed the variables associated with a low-grade coeliac enteropathy diagnosis in patients with suspected coeliac disease but without villous atrophy, and developed a scoring system to identify them. Methods: We collected data from 2010 through to 2016 on patients with lymphocytic enteritis and persistent symptoms compatible with the clinical spectrum of coeliac disease. One hundred and four patients starting on a gluten-free diet (GFD) were included. Duodenal biopsies were collected before the GFD and analysed for numbers of CD3+ T-cell receptor gamma delta+ (TCRγδ+), and CD3- intraepithelial lymphocytes. We performed a logistic regression analysis to identify factors associated with a low-grade coeliac enteropathy diagnosis. Results: Sixty-two patients achieved clinical remission after the GFD. Fifty of these 62 patients were diagnosed with low-grade coeliac enteropathy. Multivariate analysis identified the presence of >25% intraepithelial lymphocytosis, HLA-DQ2.5, positive serology, and increased numbers of TCRγδ+ cells with a low-grade coeliac enteropathy diagnosis. We developed a scoring system that identified patients with an area under the ROC curve (AUC) of 0.91. Scores of >10 had 86% sensitivity and 85% specificity. Conclusion: We developed a scoring system that identifies patients likely to be diagnosed with low-grade coeliac enteropathy with an AUC value of 0.91. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/nu11051050 | - |
dc.relation.ispartof | Nutrients, 2019, vol. 11, num. 5, p. 1050 | - |
dc.relation.uri | https://doi.org/10.3390/nu11051050 | - |
dc.rights | cc-by (c) Fernández Bañares, Fernando et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malaltia celíaca | - |
dc.subject.classification | Terapèutica | - |
dc.subject.other | Celiac disease | - |
dc.subject.other | Therapeutics | - |
dc.title | A Scoring System for Identifying Patients Likely to Be Diagnosed with Low-Grade Coeliac Enteropathy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 692108 | - |
dc.date.updated | 2021-04-08T10:10:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31083384 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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692108.pdf | 984.23 kB | Adobe PDF | View/Open |
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