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http://hdl.handle.net/2445/176069
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DC Field | Value | Language |
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dc.contributor.author | Almanza Aguilera, Enrique | - |
dc.contributor.author | Hernáez Camba, Álvaro | - |
dc.contributor.author | Corella Piquer, Dolores | - |
dc.contributor.author | Sanllorente, Albert | - |
dc.contributor.author | Ros Rahola, Emilio | - |
dc.contributor.author | Portoles, Olga | - |
dc.contributor.author | Valussi, Julieta | - |
dc.contributor.author | Estruch Riba, Ramon | - |
dc.contributor.author | Coltell, Óscar | - |
dc.contributor.author | Subirana Cachinero, Isaac | - |
dc.contributor.author | Canudas Puig, Sílvia | - |
dc.contributor.author | Razquin, Cristina | - |
dc.contributor.author | Blanchart, Gemma | - |
dc.contributor.author | Nonell, Lara | - |
dc.contributor.author | Fitó Colomer, Montserrat | - |
dc.contributor.author | Castañer, Olga | - |
dc.date.accessioned | 2021-04-08T13:45:38Z | - |
dc.date.available | 2021-04-08T13:45:38Z | - |
dc.date.issued | 2020-12-29 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176069 | - |
dc.description.abstract | We aimed to explore the differences in the whole transcriptome of peripheral blood mononuclear cells between elderly individuals with and without type 2 diabetes (T2D). We conducted a microarray-based transcriptome analysis of 19 individuals with T2D and 15 without. Differentially expressed genes according to linear models were submitted to the Ingenuity Pathway Analysis system to conduct a functional enrichment analysis. We established that diseases, biological functions, and canonical signaling pathways were significantly associated with T2D patients when their logarithms of Benjamini-Hochberg-adjusted p-value were >1.30 and their absolute z-scores were >2.0 (≥2.0 meant 'upregulation' and ≤ -2.0 'downregulation'). Cancer signaling pathways were the most upregulated ones in T2D (z-score = 2.63, -log(p-value) = 32.3; 88.5% (n = 906) of the total differentially expressed genes located in these pathways). In particular, integrin (z-score = 2.52, -log(p-value) = 2.03) and paxillin (z-score = 2.33, -log(p-value) = 1.46) signaling pathways were predicted to be upregulated, whereas the Rho guanosine diphosphate (Rho-GDP) dissociation inhibitor signaling pathway was predicted to be downregulated in T2D individuals (z-score = -2.14, -log(p-value) = 2.41). Our results suggest that, at transcriptional expression level, elderly individuals with T2D present an increased activation of signaling pathways related to neoplastic processes, T-cell activation and migration, and inflammation. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm10010085 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2020, vol. 10, num. 1, p. 85 | - |
dc.relation.uri | https://doi.org/10.3390/jcm10010085 | - |
dc.rights | cc-by (c) Almanza Aguilera, Enrique et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Diabetis no-insulinodependent | - |
dc.subject.classification | Cèl·lules T | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Non-insulin-dependent diabetes | - |
dc.subject.other | T cells | - |
dc.subject.other | Cancer | - |
dc.title | Cancer Signaling Transcriptome Is Upregulated in Type 2 Diabetes Mellitus | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 706944 | - |
dc.date.updated | 2021-04-08T13:45:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33383630 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Medicina) |
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706944.pdf | 1.96 MB | Adobe PDF | View/Open |
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