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Title: Entrapment of Citrus limon var. pompia Essential Oil or Pure Citral in Liposomes Tailored as Mouthwash for the Treatment of Oral Cavity Diseases
Author: Palmas, Lucia
Aroffu, Matteo
Petretto, Giacomo L.
Escribano Ferrer, Elvira
Díez-Sales, Octavio
Usach, Iris
Peris, José Esteban
Marongiu, Francesca
Ghavam, Mansureh
Fais, Sara
Orrù, Germano
Rached, Rita Abi
Manca, Maria Letizia
Manconi, Maria
Keywords: Olis essencials
Malalties de la boca
Essences and essential oils
Mouth diseases
Issue Date: 28-Aug-2020
Publisher: MDPI
Abstract: This work aimed at developing a mouthwash based on liposomes loading Citrus limon var. pompia essential oil or citral to treat oropharyngeal diseases. Vesicles were prepared by dispersing phosphatidylcholine and pompia essential oil or citral at increasing amounts (12, 25 and 50 mg/mL) in water. Transparent vesicle dispersions were obtained by direct sonication avoiding the use of organic solvents. Cryogenic transmission electron microscopy (cryo-TEM) confirmed the formation of unilamellar, spherical and regularly shaped vesicles. Essential oil and citral loaded liposomes were small in size (~110 and ~100 nm, respectively) and negatively charged. Liposomes, especially those loading citral, were highly stable as their physico-chemical properties did not change during storage. The formulations were highly biocompatible against keratinocytes, were able to counteract the damages induced in cells by using hydrogen peroxide, and able to increase the rate of skin repair. In addition, liposomes loading citral at higher concentrations inhibited the proliferation of cariogenic bacterium
Note: Reproducció del document publicat a:
It is part of: Pharmaceuticals, 2020, vol. 13, num. 9, p. 216
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ISSN: 1424-8247
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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