Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/176092
Title: | Childhood maltreatment interacts with hypothalamic-pituitary-adrenal axis negative feedback and major depression: effects on cognitive performance |
Author: | Salvat Pujol, Neus Labad, Javier Urretavizcaya Sarachaga, Mikel Arriba Arnau, Aida de Segalàs Cosi, Cinto Real, Eva Ferrer, Alex Crespo, José M. Jiménez-Murcia, Susana Soriano Mas, Carles Menchón Magriñá, José Manuel Soria, Virginia |
Keywords: | Maltractament infantil Depressió psíquica Trastorns cognitius Child abuse Cognition disorders Mental depression |
Issue Date: | 1-Jan-2021 |
Publisher: | Informa UK Limited |
Abstract: | Background: Childhood maltreatment (CM) is associated with impaired hypothalamic-pituitary-adrenal (HPA) axis negative feedback and cognitive dysfunction, resembling those abnormalities linked to major depressive disorder (MDD). Objectives: We aimed to assess the potential modulating effects of MDD diagnosis or HPA axis function in the association between different types of CM and cognitive performance in adulthood. Methods: Sixty-eight MDD patients and 87 healthy controls were recruited. CM was assessed with the Childhood Trauma Questionnaire. We obtained three latent variables for neuropsychological performance (verbal memory, visual memory and executive function/processing speed) after running a confirmatory factor analysis with cognitive tests applied. Dexamethasone suppression test ratio (DSTR) was performed using dexamethasone 0.25 mg. Results: Different types of CM had different effects on cognition, modulated by MDD diagnosis and HPA axis function. Individuals with physical maltreatment and MDD presented with enhanced cognition in certain domains. The DSTR differentially modulated the association between visual memory and physical neglect or sexual abuse. Conclusions: HPA axis-related neurobiological mechanisms leading to cognitive impairment might differ depending upon the type of CM. Our results suggest a need for early assessment and intervention on cognition and resilience mechanisms in individuals exposed to CM to minimize its deleterious and lasting effects. |
Note: | Reproducció del document publicat a: https://doi.org/10.1080/20008198.2020.1857955 |
It is part of: | European Journal of Psychotraumatology, 2021, vol. 12, issue. 1, p. 1857955 |
URI: | http://hdl.handle.net/2445/176092 |
Related resource: | https://doi.org/10.1080/20008198.2020.1857955 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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