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http://hdl.handle.net/2445/176098
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DC Field | Value | Language |
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dc.contributor.author | Griguolo, Gaia | - |
dc.contributor.author | Serna, G. | - |
dc.contributor.author | Pascual, Tomás | - |
dc.contributor.author | Fasani, R. | - |
dc.contributor.author | Guardia, X. | - |
dc.contributor.author | Chic, Núria | - |
dc.contributor.author | Paré, Laia | - |
dc.contributor.author | Pernas, Sònia | - |
dc.contributor.author | Muñoz Mateu, Montserrat | - |
dc.contributor.author | Oliveira, Mafalda | - |
dc.contributor.author | Vidal, M. | - |
dc.contributor.author | Llombart Cussac, Antonio | - |
dc.contributor.author | Cortés, Javier | - |
dc.contributor.author | Galván, Patricia | - |
dc.contributor.author | Bermejo de las Heras, Begoña | - |
dc.contributor.author | Martínez, N. | - |
dc.contributor.author | López, R. | - |
dc.contributor.author | Morales, Serafín | - |
dc.contributor.author | Garau, Isabel | - |
dc.contributor.author | Manso, Luis | - |
dc.contributor.author | Alarcón, Jesús | - |
dc.contributor.author | Martínez, E. | - |
dc.contributor.author | Villagrasa, Patricia | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.contributor.author | Nuciforo, Paolo | - |
dc.date.accessioned | 2021-04-08T15:40:03Z | - |
dc.date.available | 2021-04-08T15:40:03Z | - |
dc.date.issued | 2021-03-19 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176098 | - |
dc.description.abstract | Despite their recognised role in HER2-positive (HER2+) breast cancer (BC), the composition, localisation and functional orientation of immune cells within tumour microenvironment, as well as its dynamics during anti-HER2 treatment, is largely unknown. We here investigate changes in tumour-immune contexture, as assessed by stromal tumour-infiltrating lymphocytes (sTILs) and by multiplexed spatial cellular phenotyping, during treatment with lapatinib-trastuzumab in HER2+ BC patients (PAMELA trial). Moreover, we evaluate the relationship of tumour-immune contexture with hormone receptor status, intrinsic subtype and immune-related gene expression. sTIL levels increase after 2 weeks of HER2 blockade in HR-negative disease and HER2-enriched subtype. This is linked to a concomitant increase in cell density of all four immune subpopulations (CD3+, CD4+, CD8+, Foxp3+). Moreover, immune contexture analysis showed that immune cells spatially interacting with tumour cells have the strongest association with response to anti-HER2 treatment. Subsequently, sTILs consistently decrease at the surgery in patients achieving pathologic complete response, whereas most residual tumours at surgery remain inflamed, possibly reflecting a progressive loss of function of T cells. Understanding the features of the resulting tumour immunosuppressive microenvironment has crucial implications for the design of new strategies to de-escalate or escalate systemic therapy in early-stage HER2+ BC. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41698-021-00163-6 | - |
dc.relation.ispartof | npj Precision Oncology, 2021, vol. 5, num.23 | - |
dc.relation.uri | https://doi.org/10.1038/s41698-021-00163-6 | - |
dc.rights | cc by (c) Griguolo, G. et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Pronòstic mèdic | - |
dc.subject.classification | Expressió gènica | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Prognosis | - |
dc.subject.other | Gene expression | - |
dc.title | Immune microenvironment characterisation and dynamics during anti-HER2-based neoadjuvant treatment in HER2-positive breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2021-04-08T08:57:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33742063 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
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s41698-021-00163-6.pdf | 3.41 MB | Adobe PDF | View/Open |
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