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Title: Gender-Based Differences by Age Range in Patients Hospitalized with COVID-19: A Spanish Observational Cohort Study
Author: Josa Laorden, Claudia
Crestelo Vieitez, Anxela
García Andreu, María
Rubio-Rivas, Manuel
Sánchez, Marcos
Toledo Samaniego, Neera
Arnalich Fernández, Francisco
Iguaran Bermudez, Rosario
Fonseca Aizpuru, Eva
Vargas Núñez, Juan
Pesqueira Fontan, Paula
Serrano Ballesteros, Jorge
Freire Castro, Santiago
Pestaña Fernández, Melani
Viana García, Alba
Nuñez Rodriguez, Victoria
Giner Galvañ, Vicente
Carrasco Sánchez, Francisco
Hernández Milián, Almudena
Cobos Siles, Marta
Napal Lecumberri, Jose
Herrero García, Virginia
Pascual Pérez, Maria
Millán Núñez-Cortés, Jesús
Casas Rojo, José
SEMI-COVID-19 Network
Keywords: Factors sexuals en les malalties
Sex factors in disease
Issue Date: 25-Feb-2021
Publisher: MDPI
Abstract: There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.
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It is part of: Journal of Clinical Medicine, 2021, vol. 10, num. 5
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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