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http://hdl.handle.net/2445/176180
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DC Field | Value | Language |
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dc.contributor.author | Cobo Dols, Manuel | - |
dc.contributor.author | Beato Zambrano, Carmen | - |
dc.contributor.author | Cabezón Gutiérrez, Luis | - |
dc.contributor.author | Chicas Sett, Rodolfo | - |
dc.contributor.author | Blancas López-Barajas, María Isabel | - |
dc.contributor.author | García Navalón, Francisco | - |
dc.contributor.author | Fírvida Pérez, José Luis | - |
dc.contributor.author | Serrano Bermúdez, Gala | - |
dc.contributor.author | Togores Torres, Pilar | - |
dc.contributor.author | Delgado Mingorance, Ignacio | - |
dc.contributor.author | Giraldo Marín, Alexandra | - |
dc.contributor.author | Librán Oriol, Anna | - |
dc.contributor.author | Paredes Lario, Alfredo | - |
dc.contributor.author | Sánchez Mauriño, Pedro | - |
dc.contributor.author | Higuera Gómez, Oliver | - |
dc.contributor.author | Moreno Muñoz, Diana | - |
dc.contributor.author | Jiménez López, Antonio Javier | - |
dc.contributor.author | Huerta González, Ibone | - |
dc.contributor.author | Sanz Yagüe, Almudena | - |
dc.contributor.author | Soler López, Begoña | - |
dc.date.accessioned | 2021-04-12T09:50:51Z | - |
dc.date.available | 2021-04-12T09:50:51Z | - |
dc.date.issued | 2020-05-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176180 | - |
dc.description.abstract | Objectives: Opioid-induced constipation (OIC) can affect up to 63% of all patients with cancer. The objectives of this study were to assess quality of life as well as efficacy and safety of naloxegol, in patients with cancer with OIC. Methods: An observational study was made of a cohort of patients with cancer and with OIC exhibiting an inadequate response to laxatives and treated with naloxegol. The sample consisted of adult outpatients with a Karnofsky performance status score ≥50. The Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) and the Patient Assessment of Constipation Symptoms (PAC-SYM) were applied for 3 months. Results: A total of 126 patients (58.2% males) with a mean age of 61.3 years (range 34-89) were included. Clinically relevant improvements (>0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p<0.0001) from 15 days of treatment. The number of days a week with complete spontaneous bowel movements increased significantly (p<0.0001) from 2.4 to 4.6 on day 15, 4.7 after 1 month and 5 after 3 months. Pain control significantly improved (p<0.0001) during follow-up. A total of 13.5% of the patients (17/126) presented some gastrointestinal adverse reaction, mostly of mild (62.5%) or moderate intensity (25%). Conclusions: Clinically relevant improvements in OIC-related quality of life, number of bowel movements and constipation-related symptoms were recorded as early as after 15 days of treatment with naloxegol in patients with cancer and OIC, with a good safety profile. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BMJ | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1136/bmjspcare-2020-002249 | - |
dc.relation.ispartof | BMJ Supportive & Palliative Care, 2020, vol. 11, num. 1, p. 25-31 | - |
dc.relation.uri | https://doi.org/10.1136/bmjspcare-2020-002249 | - |
dc.rights | cc by-nc (c) Cobo Dols et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer | - |
dc.subject.classification | Restrenyiment | - |
dc.subject.classification | Opiacis | - |
dc.subject.other | Cancer | - |
dc.subject.other | Constipation | - |
dc.subject.other | Opioids | - |
dc.title | Efficacy of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: a 3-month follow-up analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2021-04-08T07:07:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32376758 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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bmjspcare-2020-002249.full.pdf | 508.04 kB | Adobe PDF | View/Open |
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