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http://hdl.handle.net/2445/176242
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DC Field | Value | Language |
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dc.contributor.author | Sainz, Juan | - |
dc.contributor.author | García Verdejo, Francisco José | - |
dc.contributor.author | Martínez Bueno, Manuel | - |
dc.contributor.author | Kumar, Abhishek | - |
dc.contributor.author | Sánchez Maldonado, José Manuel | - |
dc.contributor.author | Díez Villanueva, Anna | - |
dc.contributor.author | Vodičková, Ludmila | - |
dc.contributor.author | Vymetálková, Veronika | - |
dc.contributor.author | Martín Sánchez, Vicente | - |
dc.contributor.author | Silva Filho, Miguel Inacio Da | - |
dc.contributor.author | Sampaio Marques, Belém | - |
dc.contributor.author | Brezina, Stefanie | - |
dc.contributor.author | Butterbach, Katja | - |
dc.contributor.author | Ter Horst, Rob | - |
dc.contributor.author | Hoffmeister, Michael | - |
dc.contributor.author | Ludovico, Paula | - |
dc.contributor.author | Jurado, Manuel | - |
dc.contributor.author | Li, Yang | - |
dc.contributor.author | Sánchez Rovira, Pedro | - |
dc.contributor.author | Netea, Mihai G. | - |
dc.contributor.author | Gsur, Andrea | - |
dc.contributor.author | Vodička, Pavel | - |
dc.contributor.author | Moreno Aguado, Víctor | - |
dc.contributor.author | Hemminki, Kari | - |
dc.contributor.author | Brenner, Hermann | - |
dc.contributor.author | Chang-Claude, Jenny | - |
dc.contributor.author | Försti, Asta | - |
dc.date.accessioned | 2021-04-15T14:42:26Z | - |
dc.date.available | 2021-04-15T14:42:26Z | - |
dc.date.issued | 2021-03-12 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176242 | - |
dc.description.abstract | The role of genetic variation in autophagy-related genes in modulating autophagy and cancer is poorly understood. Here, we comprehensively investigated the association of autophagy-related variants with colorectal cancer (CRC) risk and provide new insights about the molecular mechanisms underlying the associations. After meta-analysis of the genome-wide association study (GWAS) data from four independent European cohorts (8006 CRC cases and 7070 controls), two loci, DAPK2 (p = 2.19 × 10-5) and ATG5 (p = 6.28 × 10-4) were associated with the risk of CRC. Mechanistically, the DAPK2rs11631973G allele was associated with IL1 β levels after the stimulation of peripheral blood mononuclear cells (PBMCs) with Staphylococcus aureus (p = 0.002), CD24 + CD38 + CD27 + IgM + B cell levels in blood (p = 0.0038) and serum levels of en-RAGE (p = 0.0068). ATG5rs546456T allele was associated with TNF α and IL1 β levels after the stimulation of PBMCs with LPS (p = 0.0088 and p = 0.0076, respectively), CD14+CD16- cell levels in blood (p = 0.0068) and serum levels of CCL19 and cortisol (p = 0.0052 and p = 0.0074, respectively). Interestingly, no association with autophagy flux was observed. These results suggested an effect of the DAPK2 and ATG5 loci in the pathogenesis of CRC, likely through the modulation of host immune responses. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers13061258 | - |
dc.relation.ispartof | Cancers, 2021, vol. 13, num. 6 | - |
dc.relation.uri | https://doi.org/10.3390/cancers13061258 | - |
dc.rights | cc by (c) Sainz et al., 2021 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Autofàgia | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Autophagy | - |
dc.title | Polymorphisms within Autophagy-Related Genes Influence the Risk of Developing Colorectal Cancer: A Meta-Analysis of Four Large Cohorts | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 721417 | - |
dc.date.updated | 2021-04-15T14:28:52Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/856620/EU//Chaperon | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33809172 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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cancers-13-01258-v3.pdf | 1.6 MB | Adobe PDF | View/Open |
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