Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176296
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dc.contributor.authorIzquierdo, Vanesa-
dc.contributor.authorPalomera Ávalos, Verónica-
dc.contributor.authorPallàs i Llibería, Mercè, 1964--
dc.contributor.authorGriñán Ferré, Christian-
dc.date.accessioned2021-04-15T05:42:57Z-
dc.date.available2021-04-15T05:42:57Z-
dc.date.issued2021-02-01-
dc.identifier.issn1661-6596-
dc.identifier.urihttp://hdl.handle.net/2445/176296-
dc.description.abstractEnvironmental factors such as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride levels in a high-fat diet with resveratrol (RSV) HFD + RSV group and the offspring. Firstly, we obtained better cognitive performance in HFD+RSV groups and their offspring. Molecularly, a significant increase in DNA methylation (5-mC) levels, as well as increased gene expression of DNA methyltransferase 1 (Dnmt1) and Dnmt3a in HFD + RSV F1 group, were found. Furthermore, a significant increase of N6-Methyladenosine methylation (m6A) levels in HFD+RSV F1, as well as changes in gene expression of its enzymes Methyltransferase like 3 (Mettl3) and FTO alpha-ketoglutarate dependent dioxygenase (Fto) were found. Moreover, we found a decrease in gene expression levels of proinflammatory markers such as Interleukin 1β (Il1-β), Interleukin 6 (Il-6), Tumor necrosis factor-α (Tnf- α), C-X-C motif chemokine ligand 10 (Cxcl-10), the pro-inflammatory factors monocyte chemoattractant protein 1 (Mcp-1) and Tumor growth factor-β1 (Tgf-β1) in HFD+RSV and HFD+RSV F1 groups. Moreover, there was increased gene expression of neurotrophins such as Neural growth factor (Ngf), Neurotrophin-3 (Nt3), and its receptors Tropomyosin receptor kinase TrkA and TrkB. Likewise, an increase in protein levels of brain-derived neurotrophic factor (BDNF) and phospho-protein kinase B (p-Akt) in HFD+RSV F1 was found. These results suggest that maternal RSV supplementation under HFD intake prevents cognitive decline in senescence-accelerated mice prone 8 (SAMP8) adult offspring, promoting a reduction in triglycerides and leptin plasma levels, changes in the pro-inflammatory profile, and restoring the epigenetic landscape as well as synaptic plasticity.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/ijms22031453-
dc.relation.ispartofInternational Journal of Molecular Sciences, 2021, vol. 22, num. 3, p. 1453-
dc.relation.urihttps://doi.org/10.3390/ijms22031453-
dc.rightscc-by (c) Izquierdo, Vanesa et al., 2021-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.subject.classificationEpigenètica-
dc.subject.classificationEnvelliment-
dc.subject.classificationCognició-
dc.subject.classificationMalalties neurodegeneratives-
dc.subject.otherEpigenetics-
dc.subject.otherAging-
dc.subject.otherCognition-
dc.subject.otherNeurodegenerative Diseases-
dc.titleResveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations. Izquierdo V, Palomera-Ávalos V, Pallàs M, Griñán-Ferré C.-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec709018-
dc.date.updated2021-04-15T05:42:57Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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