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DC Field | Value | Language |
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dc.contributor.author | Camilleri-Robles, Carlos | - |
dc.contributor.author | Serras Rigalt, Florenci | - |
dc.contributor.author | Corominas, Montserrat (Corominas Guiu) | - |
dc.date.accessioned | 2021-04-15T09:21:50Z | - |
dc.date.available | 2021-04-15T09:21:50Z | - |
dc.date.issued | 2019-05-18 | - |
dc.identifier.issn | 2073-4425 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176303 | - |
dc.description.abstract | The GADD45 proteins are induced in response to stress and have been implicated in the regulation of several cellular functions, including DNA repair, cell cycle control, senescence, and apoptosis. In this study, we investigate the role of D-GADD45 during Drosophila development and regeneration of the wing imaginal discs. We find that higher expression of D-GADD45 results in JNK-dependent apoptosis, while its temporary expression does not have harmful effects. Moreover, D-GADD45 is required for proper regeneration of wing imaginal discs. Our findings demonstrate that a tight regulation of D-GADD45 levels is required for its correct function both, in development and during the stress response after cell death. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/genes10050378 | - |
dc.relation.ispartof | Genes, 2019, vol. 10, num. 5, p. 378 | - |
dc.relation.uri | https://doi.org/10.3390/genes10050378 | - |
dc.rights | cc-by (c) Camilleri Robles, Carlos et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Proteïnes G | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Drosòfila | - |
dc.subject.other | G Proteins | - |
dc.subject.other | DNA | - |
dc.subject.other | Drosophila | - |
dc.title | Role of D-GADD45 in JNK-Dependent Apoptosis and Regeneration in Drosophila | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695178 | - |
dc.date.updated | 2021-04-15T09:21:50Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31109086 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
Files in This Item:
File | Description | Size | Format | |
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695178.pdf | 5.01 MB | Adobe PDF | View/Open |
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