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http://hdl.handle.net/2445/176331
Title: | TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression |
Author: | Kälin, Roland E. Cai, Linzhi Li, Yuping Zhao, Dongxu Zhang, Huabin Cheng, Jiying Zhang, Wenlong Wu, Yingxi Eisenhut, Katharina Janssen, Philipp Schmitt, Lukas Enard, Wolfgang Michels, Friederike Flüh, Charlotte Hou, Mengzhuo Kirchleitner, Sabrina V. Siller, Sebastian Schiemann, Matthias Andrä, Immanuel Montañez, Eloi Giachino, Claudio Taylor, Verdon Synowitz, Michael Tonn, Jörg-Christian Baumgarten, Louisa von Schulz, Christian Hellmann, Ines Glass, Rainer |
Keywords: | Angiogènesi Tumors cerebrals Glioma Micròglia Macròfags Neovascularization Brain tumors Gliomas Microglia Macrophages |
Issue Date: | 17-Mar-2021 |
Publisher: | Elsevier |
Abstract: | Aggressive brain tumors like glioblastoma depend on support by their local environment and subsets of tumor parenchymal cells may promote specific phases of disease progression. We investigated the glioblastoma microenvironment with transgenic lineage-tracing models, intravital imaging, single-cell transcriptomics, immunofluorescence analysis as well as histopathology and characterized a previously unacknowledged population of tumor-associated cells with a myeloid-like expression profile (TAMEP) that transiently appeared during glioblastoma growth. TAMEP of mice and humans were identified with specific markers. Notably, TAMEP did not derive from microglia or peripheral monocytes but were generated by a fraction of CNS-resident, SOX2-positive progenitors. Abrogation of this progenitor cell population, by conditional Sox2-knockout, drastically reduced glioblastoma vascularization and size. Hence, TAMEP emerge as a tumor parenchymal component with a strong impact on glioblastoma progression. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.cels.2021.01.002 |
It is part of: | Cell Systems, 2021, vol. 12, num. 3, p. 248-262 |
URI: | http://hdl.handle.net/2445/176331 |
Related resource: | https://doi.org/10.1016/j.cels.2021.01.002 |
ISSN: | 2405-4712 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Fisiològiques) |
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