Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/176410
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Giorgetti, Alessandra | - |
dc.contributor.author | Montserrat, Núria | - |
dc.contributor.author | Aasen, Trond | - |
dc.contributor.author | Gonzalez, Federico | - |
dc.contributor.author | Rodríguez-Pizà, Ignacio | - |
dc.contributor.author | Vassena, Rita | - |
dc.contributor.author | Raya Chamorro, Ángel | - |
dc.contributor.author | Boué, Stefanie | - |
dc.contributor.author | Barrero, Maria J. | - |
dc.contributor.author | Aran Corbella, Begoña | - |
dc.contributor.author | Torrabadella, Marta | - |
dc.contributor.author | Veiga, Anna | - |
dc.contributor.author | Izpisúa Belmonte, Juan Carlos | - |
dc.date.accessioned | 2021-04-20T11:39:29Z | - |
dc.date.available | 2021-04-20T11:39:29Z | - |
dc.date.issued | 2009-10-02 | - |
dc.identifier.issn | 1934-5909 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176410 | - |
dc.description.abstract | Mouse and human fibroblasts were the first cell types successfully reprog- rammed by ectopic expression of OCT4, SOX2, KLF4, and c-MYC (OSKM) (Lowry et al., 2008; Maherali et al., 2007; Park et al., 2008; Takahashi et al., 2007; Taka- hashi and Yamanaka, 2006; Yu et al., 2007). Further studies have shown that the age, origin, and cell type used have a deep impact on the reprogramming effi- ciency, eventually requiring the expres- sion of fewer factors and/or reducing the timing of the whole process. In general, stem cells are rare and difficult to access and isolate in large numbers (neural stem cells, for instance [Kim et al., 2008, 2009c]) and, therefore, represent a com- plicated target for reprogramming. How- ever, Cord Blood (CB) could represent an alternative and readily accessible source of stem cells. Here, we describe reprog- ramming of CB cells to pluripotency by retroviral transduction of four (OSKM), three (OSK), and as few as two (OS) tran- scription factors, without the need for additional chemical compounds. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.stem.2009.09.008 | - |
dc.relation.ispartof | Cell Stem Cell, 2009, vol. 5, num. 4, p. 353-357 | - |
dc.relation.uri | https://doi.org/10.1016/j.stem.2009.09.008 | - |
dc.rights | (c) Elsevier B.V., 2009 | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Cèl·lules mare | - |
dc.subject.classification | Cordó umbilical | - |
dc.subject.classification | Citologia | - |
dc.subject.other | Stem cells | - |
dc.subject.other | Umbilical cord | - |
dc.subject.other | Cytology | - |
dc.title | Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 711108 | - |
dc.date.updated | 2021-04-20T11:39:29Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 19796614 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
711108.pdf | 1.26 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.