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http://hdl.handle.net/2445/176477
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DC Field | Value | Language |
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dc.contributor.author | Rupérez, Celia | - |
dc.contributor.author | Ferrer Curriu, Gemma | - |
dc.contributor.author | Cervera Barea, Aina | - |
dc.contributor.author | Florit, Laura | - |
dc.contributor.author | Guitart Mampel, Mariona | - |
dc.contributor.author | Garrabou Tornos, Glòria | - |
dc.contributor.author | Zamora, Monica | - |
dc.contributor.author | Crispi Brillas, Fàtima | - |
dc.contributor.author | Fernández-Solà, J. (Joaquim) | - |
dc.contributor.author | Lupón, Josep | - |
dc.contributor.author | Bayés Genís, Antoni | - |
dc.contributor.author | Villarroya i Gombau, Francesc | - |
dc.contributor.author | Planavila Porta, Ana | - |
dc.date.accessioned | 2021-04-19T15:55:53Z | - |
dc.date.available | 2021-08-26T05:10:20Z | - |
dc.date.issued | 2021-05-03 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176477 | - |
dc.description.abstract | Meteorin-like/Meteorin-β (Metrnl/Metrnβ) is a secreted protein produced by skeletal muscle and adipose tissue that exerts metabolic actions that improve glucose metabolism. The role of Metrnβ in cardiac disease is completely unknown. Here, we show that Metrnβ-null mice exhibit asymmetrical cardiac hypertrophy, fibrosis, and enhanced signs of cardiac dysfunction in response to isoproterenol-induced cardiac hypertrophy and aging. Conversely, adeno-associated virus-mediated specific overexpression of Metrnβ in the heart prevents the development of cardiac remodeling. Furthermore, Metrnβ inhibits cardiac hypertrophy development in cardiomyocytes in vitro, indicating a direct effect on cardiac cells. Antibody-mediated blockage of Metrnβ in cardiomyocyte cell cultures indicated an autocrine action of Metrnβ on the heart, in addition to an endocrine action. Moreover, Metrnβ is highly produced in the heart, and analysis of circulating Metrnβ concentrations in a large cohort of patients reveals that it is a new biomarker of heart failure with an independent prognostic value. | - |
dc.format.extent | 21 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Rockefeller University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1084/jem.20201206 | - |
dc.relation.ispartof | Journal of Experimental Medicine, 2021, vol. 218, num. 5, p. e20201206 | - |
dc.relation.uri | https://doi.org/10.1084/jem.20201206 | - |
dc.rights | (c) Rockefeller University Press, 2021 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Malalties cardiovasculars | - |
dc.subject.classification | Metabolisme de proteïnes | - |
dc.subject.other | Cardiovascular diseases | - |
dc.subject.other | Protein metabolism | - |
dc.title | Meteorin-like/ Meteorin-b protects heart against cardiac dysfunction | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 704526 | - |
dc.date.updated | 2021-04-19T15:55:53Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 33635944 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (BCNatal Fetal Medicine Research Center) Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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704526.pdf | 5.06 MB | Adobe PDF | View/Open |
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