Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176627
Title: Changed expression of cytoskeleton proteins during lung injury in a mouse model of Streptococcus pneumoniae infection
Author: Ferrer Navarro, Mario
Strehlitz, Anja
Medina, Eva
Vila Estapé, Jordi
Keywords: Pneumococs
Proteïnes citosquelètiques
Streptococcus pneumonia
Cytoskeletal proteins
Issue Date: 8-May-2018
Publisher: Frontiers Media
Abstract: Infections by Streptococcus pneumoniae are a major cause of morbidity and mortality worldwide, often causing community-acquired pneumonia, otitis media and also bacteremia and meningitis. Studies on S. pneumoniae are mainly focused on its virulence or capacity to evade the host immune system, but little is known about the injury caused in lungs during a pneumococcal infection. Herein we investigated this issue comparing the proteome profile of lungs from S. pneumoniae-infected mice with control mice by means of difference gel electrophoresis (DIGE) technology. In order to obtain reliable results three biological replicas were used, and four technical replicas were carried out in each biological replica. Proteomic comparison was performed at two time points: 24 and 48 h post infection. A total of 91 proteins were identified with different abundance. We found important changes in the protein profiles during pneumococcal infection mainly associated with regulation of vesicle-mediated transport, wound healing, and cytoskeleton organization. In conclusion, the results obtained show that the cytoskeleton of the host cell is modified in S. pneumoniae infection.
Note: Reproducció del document publicat a: https://doi.org/10.3389/fmicb.2018.00928
It is part of: Frontiers in Microbiology, 2018, vol. 9, num. 928
URI: http://hdl.handle.net/2445/176627
Related resource: https://doi.org/10.3389/fmicb.2018.00928
ISSN: 1664-302X
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Fonaments Clínics)

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