Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/176683
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Chunmei | - |
dc.contributor.author | Coker, Kenneth J. | - |
dc.contributor.author | Kim, Jason K. | - |
dc.contributor.author | Mora Fayos, Sílvia | - |
dc.contributor.author | Thurmond, Debbie C. | - |
dc.contributor.author | Davis, Ann C. | - |
dc.contributor.author | Yang, Baoli | - |
dc.contributor.author | Williamson, Roger A. | - |
dc.contributor.author | Shulman, Gerald I. | - |
dc.contributor.author | Pessin, Jeffrey E. | - |
dc.date.accessioned | 2021-04-23T14:19:06Z | - |
dc.date.available | 2021-04-23T14:19:06Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0021-9738 | - |
dc.identifier.uri | http://hdl.handle.net/2445/176683 | - |
dc.description.abstract | To investigate the physiological function of syntaxin 4 in the regulation of GLUT4 vesicle trafficking, we used homologous recombination to generate syntaxin 4-knockout mice. Homozygotic disruption of the syntaxin 4 gene results in early embryonic lethality, whereas heterozygous knockout mice, Syn4+/-, had normal viability with no significant impairment in growth, development, or reproduction. However, the Syn4+/- mice manifested impaired glucose tolerance with a 50% reduction in whole-body glucose uptake. This defect was attributed to a 50% reduction in skeletal muscle glucose transport determined by 2-deoxyglucose uptake during hyperinsulinemic-euglycemic clamp procedures. In parallel, insulin-stimulated GLUT4 translocation in skeletal muscle was also significantly reduced in these mice. In contrast, Syn4+/- mice displayed normal insulin-stimulated glucose uptake and metabolism in adipose tissue and liver. Together, these data demonstrate that syntaxin 4 plays a critical physiological role in insulin-stimulated glucose uptake in skeletal muscle. Furthermore, reduction in syntaxin 4 protein levels in this tissue can account for the impairment in whole-body insulin-stimulated glucose metabolism in this animal model. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Society for Clinical Investigation | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1172/jci12274 | - |
dc.relation.ispartof | Journal of Clinical Investigation, 2001, vol. 107, p. 1311-1318. | - |
dc.relation.uri | https://doi.org/10.1172/jci12274 | - |
dc.rights | (c) American Society for Clinical Investigation, 2001 | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Glucosa | - |
dc.subject.classification | Teixit adipós | - |
dc.subject.classification | Resistència a la insulina | - |
dc.subject.other | Glucose | - |
dc.subject.other | Adipose tissues | - |
dc.subject.other | Insulin resistance | - |
dc.title | Syntaxin 4 heteozygous knock-out mice develop muscle insulin resistance | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 711513 | - |
dc.date.updated | 2021-04-23T14:19:06Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 11375421 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
711513.pdf | 837.7 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.