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dc.contributor.authorChoi, Jee-Eun-
dc.contributor.authorSebastián, Carlos-
dc.contributor.authorFerrer, Christina M.-
dc.contributor.authorLewis, Caroline A.-
dc.contributor.authorSade Feldman, Moshe-
dc.contributor.authorLaSalle, Thomas-
dc.contributor.authorGonye, Anna-
dc.contributor.authorLopez, Begona G. C.-
dc.contributor.authorAbdelmoula, Walid M.-
dc.contributor.authorRegan, Michael S.-
dc.contributor.authorCetinbas, Murat-
dc.contributor.authorPascual, Gloria-
dc.contributor.authorWojtkiewicz, Gregory R.-
dc.contributor.authorSilveira, Giorgia G.-
dc.contributor.authorBoon, Ruben-
dc.contributor.authorRoss, Kenneth N.-
dc.contributor.authorTirosh, Itary-
dc.contributor.authorSaladi, Srinivas V.-
dc.contributor.authorEllisen, Leif W.-
dc.contributor.authorSadreyev, Ruslan I.-
dc.contributor.authorAznar Benitah, Salvador-
dc.contributor.authorAgar, Nathalie Y. R.-
dc.contributor.authorHacohen, Nir-
dc.contributor.authorMostoslavsky, Raúl-
dc.description.abstractHead and neck squamous cell carcinoma (SCC) remains among the most aggressive human cancers. Tumour progression and aggressiveness in SCC are largely driven by tumour-propagating cells (TPCs). Aerobic glycolysis, also known as the Warburg effect, is a characteristic of many cancers; however, whether this adaptation is functionally important in SCC, and at which stage, remains poorly understood. Here, we show that the NAD+-dependent histone deacetylase sirtuin 6 is a robust tumour suppressor in SCC, acting as a modulator of glycolysis in these tumours. Remarkably, rather than a late adaptation, we find enhanced glycolysis specifically in TPCs. More importantly, using single-cell RNA sequencing of TPCs, we identify a subset of TPCs with higher glycolysis and enhanced pentose phosphate pathway and glutathione metabolism, characteristics that are strongly associated with a better antioxidant response. Together, our studies uncover enhanced glycolysis as a main driver in SCC, and, more importantly, identify a subset of TPCs as the cell of origin for the Warburg effect, defining metabolism as a key feature of intra-tumour
dc.publisherSpringer Natureca
dc.relation.isformatofVersió postprint del document publicat a:
dc.relation.ispartofNature Metabolism, 2021, Vol. 3, num. 2, p. 182-195-
dc.rights(c) Springer Nature, 2021-
dc.subject.classificationCàncer de coll-
dc.subject.classificationCàncer de cap-
dc.subject.classificationProliferació cel·lular-
dc.subject.otherNeck cancer-
dc.subject.otherHead cancer-
dc.subject.otherCell proliferation-
dc.titleA unique subset of glycolytic tumour-propagating cells drives squamous cell carcinomaca
Appears in Collections:Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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