Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/176771
Title: In vivo hippocampal subfield volumes in bipolar disorder-A mega-analysis from The Enhancing Neuro Imaging Genetics through Meta-Analysis Bipolar Disorder Working Group Hum Brain Mapp
Author: Vieta i Pascual, Eduard, 1963-
Goikolea, José Manuel
Fatjó-Vilas Mestre, Mar
ENIGMA Bipolar Disorder Working Group
Keywords: Trastorn bipolar
Hipocamp (Cervell)
Liti
Manic-depressive illness
Hippocampus (Brain)
Lithium
Issue Date: 19-Oct-2020
Publisher: Wiley
Abstract: The hippocampus consists of anatomically and functionally distinct subfields that may be differentially involved in the pathophysiology of bipolar disorder (BD). Here we, the Enhancing NeuroImaging Genetics through Meta-Analysis Bipolar Disorder workinggroup, study hippocampal subfield volumetry in BD. T1-weighted magnetic resonance imaging scans from 4,698 individuals (BD = 1,472, healthy controls [HC] = 3,226) from 23 sites worldwide were processed with FreeSurfer. We used linear mixed-effects models and mega-analysis to investigate differences in hippocampal subfield volumes between BD and HC, followed by analyses of clinical characteristics and medication use. BD showed significantly smaller volumes of the whole hippocampus (Cohen's d = -0.20), cornu ammonis (CA)1 (d = -0.18), CA2/3 (d = -0.11), CA4 (d = -0.19), molecular layer (d = -0.21), granule cell layer of dentate gyrus (d = -0.21), hippocampal tail (d = -0.10), subiculum (d = -0.15), presubiculum (d = -0.18), and hippocampal amygdala transition area (d = -0.17) compared to HC. Lithium users did not show volume differences compared to HC, while non-users did. Antipsychotics or antiepileptic use was associated with smaller volumes. In this largest study of hippocampal subfields in BD to date, we show widespread reductions in nine of 12 subfields studied. The associations were modulated by medication use and specifically the lack of differences between lithium users and HC supports a possible protective role of lithium in BD.
Note: Reproducció del document publicat a: https://doi.org/10.1002/hbm.25249
It is part of: Human Brain Mapping, 2020, vol. 2020
URI: http://hdl.handle.net/2445/176771
Related resource: https://doi.org/10.1002/hbm.25249
ISSN: 1065-9471
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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